Szczegóły publikacji
Opis bibliograficzny
Poly($\varepsilon$-caprolactone)-based composites modified with polymer-grafted magnetic nanoparticles and L-ascorbic acid for bone tissue engineering / Anna Hlukhaniuk, Małgorzata Świętek, Vitalii Patsula, Jiří Hodan, Olga Janoušková, Lukáš Bystrianský, Antonín Brož, Marina Malić, Beata Zasońska, Waldemar TOKARZ, Lucie Bačáková, Daniel Horák // Journal of Biomedical Materials Research . Part B, Applied Biomaterials ; ISSN 1552-4973. — 2024 — vol. 112 iss. 9 art. no. e35480, s. 1–14. — Bibliogr. s. 12–14, Abstr. — Publikacja dostępna online od: 2024-09-02
Autorzy (12)
- Hlukhaniuk Anna
- Świętek Małgorzata
- Patsula Vitalii
- Hodan Jiří
- Janoušková Olga
- Bystrianský Lukáš
- Brož Antonín
- Malić Marina
- Zasońska Beata
- AGHTokarz Waldemar
- Bačáková Lucie
- Horák Daniel
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 166644 |
|---|---|
| Data dodania do BaDAP | 2026-03-26 |
| Tekst źródłowy | URL |
| DOI | 10.1002/jbm.b.35480 |
| Rok publikacji | 2024 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Journal of Biomedical Materials Research, Part B, Applied Biomaterials |
Abstract
The aim of this study was to develop multifunctional magnetic poly(ε-caprolactone) (PCL) mats with antibacterial properties for bone tissue engineering and osteosarcoma prevention. To provide good dispersion of magnetic iron oxide nanoparticles (IONs), they were first grafted with PCL using a novel three-step approach. Then, a series of PCL-based mats containing a fixed amount of ION@PCL particles and an increasing content of ascorbic acid (AA) was prepared by electrospinning. AA is known for increasing osteoblast activity and suppressing osteosarcoma cells. Composites were characterized in terms of morphology, mechanical properties, hydrolytic stability, antibacterial performance, and biocompatibility. AA affected both the fiber diameter and the mechanical properties of the nanocomposites. All produced mats were nontoxic to rat bone marrow-derived mesenchymal cells; however, a composite with 5 wt.% of AA suppressed the initial proliferation of SAOS-2 osteoblast-like cells. Moreover, AA improved antibacterial properties against Staphylococcus aureus and Escherichia coli compared to PCL. Overall, these magnetic composites, reported for the very first time, can be used as scaffolds for both tissue regeneration and osteosarcoma prevention.
