Szczegóły publikacji
Opis bibliograficzny
Magnetic poly($\epsilon$-caprolactone)-based nanocomposite membranes for bone cell engineering / Małgorzata Świętek, Antonín Brož, Anna Kołodziej, Jiří Hodan, Waldemar TOKARZ, Anna Hlukhaniuk, Aleksandra Wesełucha-Briczyńska, Lucie Bačaková, Daniel Horák // Journal of Magnetism and Magnetic Materials ; ISSN 0304-8853. — 2022 — vol. 563 art. no. 169967, s. 1–11. — Bibliogr. s. 10–11, Abstr. — Publikacja dostępna online od: 2022-09-17
Autorzy (9)
- Świętek Małgorzata
- Brož Antonín
- Kołodziej Anna
- Hodan Jiří
- AGHTokarz Waldemar
- Hlukhaniuk Anna
- Wesełucha-Birczyńska Aleksandra
- Bačáková Lucie
- Horák Daniel
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 143233 |
|---|---|
| Data dodania do BaDAP | 2022-11-17 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.jmmm.2022.169967 |
| Rok publikacji | 2022 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Magnetism and Magnetic Materials |
Abstract
Magnetic polymer nanocomposites manipulatable by an external magnetic field have a great potential for bone tissue regeneration. Various strategies have been proposed for their fabrication, as uniform distribution of magnetic nanoparticles (MNPs) within the polymer matrix remains to be the main challenge. The aim of this study was to design poly(ε-caprolactone) (PCL) matrix containing iron oxide nanoparticles stabilized by saturated fatty acids with the increasing number of carbon atoms, i.e., caprylic (CA), palmitic (PA), and stearic acids (SA). We investigated the effect of the type of fatty acid and the content of particles in nanocomposite membranes on their physicochemical properties and biological response toward the SAOS-2 cells. The incorporation of the MNPs in PCL matrix resulted in a gradual increase of Young's modulus, a slight decrease of tensile strength, and a significant decrease of stress and strain at break. The addition of SA-stabilized MNPs (1 wt%) in the PCL matrix increased its strength. The membranes containing CA-stabilized MNPs remained non-toxic towards SAOS-2 cells, while the cytotoxicity of other nanocomposites increased with the enhanced length of carbon chains of fatty acids stabilizing MNPs, as well as with their increasing content in membranes.
