Szczegóły publikacji
Opis bibliograficzny
ATR-FTIR spectroscopic markers indicating drug resistance in selected Candida strains / Agnieszka DRÓŻDŻ, Dominika Kubera, Alina Olender, Wojciech Dabrowski, Magdalena Szukala, Sylwia Wosko, Joanna CHWIEJ, Marzena RUGIEŁ, Kamil KAWOŃ, Mariusz Gagoś // Scientific Reports [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 2045-2322. — 2025 — vol. 15 iss. 1 art. no. 18130, s. 1–15. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 13–14, Abstr. — Publikacja dostępna online od: 2025-05-24
Autorzy (10)
- AGHDróżdż Agnieszka
- Kubera Dominika
- Olender Alina
- Dąbrowski Wojciech
- Szukała Magdalena
- Wosko Sylwia
- AGHChwiej Joanna
- AGHRugieł Marzena
- AGHKawoń Kamil
- Gagoś Mariusz
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 160268 |
|---|---|
| Data dodania do BaDAP | 2025-06-23 |
| Tekst źródłowy | URL |
| DOI | 10.1038/s41598-025-01428-x |
| Rok publikacji | 2025 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Scientific Reports |
Abstract
The rising incidence of fungal infections and the increasing prevalence of antifungal resistance highlight the need for rapid and reliable diagnostic methods. This study investigates the potential of ATR-FTIR spectroscopy to identify spectroscopic markers of drug resistance in selected Candida strains. In this pilot study, ATR-FTIR spectroscopy was employed to analyse the biochemical composition of Candida albicans, Candida glabrata and Candida dubliniensis isolates. The minimum inhibitory concentrations (MIC) of antifungals were determined using antifungals concentration gradient strips, and the spectral data were processed to identify differences between resistant and sensitive isolates. Based on the results for Candida albicans, Candida glabrata and Candida dubliniensis, specific ATR-FITR spectroscopic markers of drug resistance were identified, which highlighted the necessity for these markers to be antifungal-specific. Despite the limitations of the study, the findings underscore the potential of ATR-FTIR spectroscopy in identifying spectroscopic markers of antifungal resistance. These preliminary results provide a foundation for further research, which could lead to the development of rapid diagnostic tools for detecting drug-resistant Candida strains, thereby improving the management and treatment of fungal infections.
