Szczegóły publikacji
Opis bibliograficzny
The blocking of drug resistance channels by selected hydrophobic statins in chemoresistance human melanoma / Wojciech Placha, Piotr SUDER, Agnieszka Panek, Patrycja Bronowicka-Adamska, Marta Zarzycka, Małgorzata Szczygieł, Jacek Zagajewski, Monika Weronika Piwowar // Biomolecules [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 2218-273X. — 2023 — vol. 13 iss. 12 art. no. 1682, s. 1-21. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 18-21, Abstr. — Publikacja dostępna online od: 2023-11-21
Autorzy (8)
- Placha Wojciech
- AGHSuder Piotr
- Panek Agnieszka
- Bronowicka-Adamska Patrycja
- Zarzycka Marta
- Szczygieł Małgorzata
- Zagajewski J.
- Piwowar Monika
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 151020 |
|---|---|
| Data dodania do BaDAP | 2024-01-05 |
| Tekst źródłowy | URL |
| DOI | 10.3390/biom13121682 |
| Rok publikacji | 2023 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Biomolecules |
Abstract
Despite the development of modern drugs, drug resistance in oncology remains the main factor limiting the curability of patients. This paper shows the use of a group of hydrophobic statins to inhibit drug resistance (Pgp protein). In a chemoresistance melanoma cell model, viability, necroptosis with DNA damage, the absorption of the applied pharmaceuticals, and the functional activity of the ABCB1 drug transporter after administration of docetaxel or docetaxel with a selected hydrophobic statin were studied. Taxol-resistant human melanoma cells from three stages of development were used as a model: both A375P and WM239A metastatic lines and radial growth phase WM35 cells. An animal model (Mus musculus SCID) was developed for the A375P cell line. The results show that hydrophobic statins administered with docetaxel increase the accumulation of the drug in the tumor cell a.o. by blocking the ABCB1 channel. They reduce taxol-induced drug resistance. The tumor size reduction was observed after the drug combination was administrated. It was shown that the structural similarity of statins is of secondary importance, e.g., pravastatin and simvastatin. Using cytostatics in the presence of hydrophobic statins increases their effectiveness while reducing their overall toxicity.
