Szczegóły publikacji
Opis bibliograficzny
Stenotic bicuspid and tricuspid aortic valves – micro-computed tomography and biological indices of calcification / Piotr Mazur, [et al.], Jacek TARASIUK, [et al.], Sebastian WROŃSKI, Katarzyna Chmielewska, [et al.] // Circulation Journal ; ISSN 1346-9843. — 2017 — vol 81 iss. 7, s. 1043–1050. — Bibliogr. s. 1049–1050. — Publikacja dostępna online od: 2017-06-23
Autorzy (13)
- Mazur Piotr
- Wypasek Ewa
- Gawęda Bogusław
- Sobczyk Dorota
- Kapusta Przemysław
- Natorska Joanna
- AGHTarasiuk Jacek
- Bochenek Maciej
- AGHWroński Sebastian
- AGHChmielewska Katarzyna
- Kapelak Bogusław
- Undas Anetta
Redaktorzy (2)
- Wypasek Ewa
- Malinowski Piotr
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 112249 |
|---|---|
| Data dodania do BaDAP | 2018-02-07 |
| Tekst źródłowy | URL |
| DOI | 10.1253/circj.CJ-16-1166 |
| Rok publikacji | 2017 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Circulation Journal |
Abstract
Background: Valve calcification is well estimated by ex-vivo micro-computed tomography (micro-CT). The objective of this study was to investigate the associations between micro-CT findings and biological indices of calcification in aortic stenosis (AS), as well as differences between bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). Methods and Results: Aortic valves and plasma were obtained from patients undergoing valve surgery. Valves were dissected and underwent micro-CT, genetic analyses, and calcium content assessment. Plasma levels of calcification markers were measured. Forty-two patients with isolated severe AS, including 22 with BAV, were studied. BAV patients had a lower median CT value (140.0 [130.0-152.0] vs. 157.0 [147.0-176.0], P=0.002) and high-density calcification (HDC) fraction (9.3 [5.7-23.3] % vs. 21.3 [14.3-31.2] %, P=0.01), as compared with TAV. Calcification fraction (CF) correlated with AS severity (measured as maximal transvalvular pressure gradient [r=0.34, P=0.03], maximal flow velocity [r=0.38, P=0.02], and indexed aortic valve area [r=-0.37, P=0.02]). For TAV patients only, mRNA expression of integrin-binding sialoprotein correlated with CF (r=0.45, P=0.048), and the receptor activator of the nuclear factor kappa-B ligand transcript correlated with HDC corrugation (r=0.54, P=0.01). Conclusions: TAV patients with AS present more mineralized calcifications in micro-CT than BAV subjects. The relative volume of calcifications increases with the AS severity. In TAV patients, upregulated expression of genes involved in osteoblastogenesis in AS correlates with leaflet mineralization in micro-CT.
