Szczegóły publikacji
Opis bibliograficzny
Dysglycaemia is associated with the pattern of valvular calcification in micro-computed tomography analysis: an observational study in patients with severe aortic stenosis / Magdalena Kopytek, Kamila W. Undas, Jacek TARASIUK, Sebastian WROŃSKI, Michał Ząbczyk, Joanna Natorska // Cardiovascular Diabetology [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1475-2840 . — 2025 — vol. 24 iss. 1 art. no. 129, s. 1–15. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 13–15, Abstr. — Publikacja dostępna online od: 2025-03-20
Autorzy (6)
- Kopytek Magdalena
- Undas Kamila W.
- AGHTarasiuk Jacek
- AGHWroński Sebastian
- Ząbczyk Michał
- Natorska Joanna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 164605 |
|---|---|
| Data dodania do BaDAP | 2025-12-10 |
| Tekst źródłowy | URL |
| DOI | 10.1186/s12933-025-02691-y |
| Rok publikacji | 2025 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Cardiovascular Diabetology |
Abstract
Background: Diabetes mellitus (DM) has been shown to increase the rate of aortic stenosis (AS) progression. However, the impact of impaired plasma glucose on valvular calcification remains poorly understood. Using ex vivo micro-computed tomography (micro-CT), we aimed to determine whether plasma glucose, glycated haemoglobin (HbA1c), or concentrations of advanced glycation end products (AGEs) and their soluble receptor (sRAGE) are associated with a specific pattern of valvular calcification in severe AS. Methods: In this case-control study, 14 (48%) normoglycaemic patients with AS were compared to 15 individuals (52%) with elevated glucose levels (≥ 5.6 mmol/L), all with HbA1c ≤ 6.5%. Stenotic aortic valves obtained surgically were analysed using micro-CT to assess structure of tissue mineralization. Calcium volume (CV), surface volume (SV), CV/SV ratio, and trabecular thickness (TbTh) were evaluated. Plasma AGEs and sRAGE were assessed by ELISAs. DM patients or those using antidiabetic agents were excluded from the study. Results: Patients with impaired and high glucose, including 10 (67%) with glucose between 5.6 and 6.9 mmol/L and 5 (33%) ranging from 7 to 7.6 mmol/L, exhibited higher HbA1c (+ 17%) and AGEs levels (+ 44.6%), but not sRAGE compared to those with normal glucose. Patients with impaired and high glucose had also 19.2% higher maximal transvalvular pressure gradient (PGmax) and 9.3% higher peak transvalvular velocity (Vmax) compared to normoglycaemic individuals. Micro-CT indices correlated with fasting glucose, HbA1c, and AGEs levels (all p < 0.05), but not with sRAGE (p > 0.05). Valves extracted from patients with impaired and high glucose exhibited higher mineralization volume, folding, and structural integrity, as reflected by increased CV (+ 127.6%), CV/SV ratio (+ 59%) and calcium deposits microarchitecture as indicated by about 50% higher TbTh, compared to normoglycaemic patients. When patients with AS were divided into three groups based on their glucose levels (< 5.5 mmol/L, 5.6–6.9 mmol/L, and 7.0–7.6 mmol/L), micro-CT analysis showed more distinct structural differences among the groups. The valves in the highest glucose group were the most severely affected. Micro-CT parameters were also associated with both transvalvular pressure gradients (PGmean and PGmax), Vmax and aortic valve area (all p < 0.05). Conclusions: Strict glycaemic control could potentially reduce the rate of valve mineralization and calcium deposit accumulation in patients with AS.
