Szczegóły publikacji
Opis bibliograficzny
High sensitive voltammetric levothyroxine sodium determination on renewable mercury film silver based electrode / Joanna SMAJDOR, Robert PIECH, Martyna RUMIN, Beata PACZOSA-BATOR, Zbigniew Smajdor // Journal of the Electrochemical Society ; ISSN 0013-4651. — 2016 — vol. 163 iss. 7, s. H605–H609. — Bibliogr. s. H608–H609. — Publikacja dostępna online od: 2016-05-07
Autorzy (5)
Dane bibliometryczne
| ID BaDAP | 98423 |
|---|---|
| Data dodania do BaDAP | 2016-08-03 |
| Tekst źródłowy | URL |
| DOI | 10.1149/2.1431607jes |
| Rok publikacji | 2016 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of the Electrochemical Society |
Abstract
Levothyroxine sodium (LS, L-T4) is a sodium salt of natural thyroid hormone thyroxine (T4), commonly used in treatment of hypothyroidism. In this work a new voltammetric method of levothyroxine sodium (LS) determination using renewable mercury film electrode is presented. A linear voltammetric response was obtained for analyte in the concentration range from 0.025·10−6 mol L−1 (1.99·10−5 g L−1) to 4.0·10−6 mol L−1 (3.19·10−3 g L−1), with a detection limit of 1.8·10−8 mol L−1 for preconcentration time of 30 s. Repeatability of method was determined as RSD % for levothyroxine sodium concentration of 0.2·10−6 mol L−1 as 1.4% (n = 9). The proposed method was successfully applied and validated by studying the recovery of levothyroxine sodium in different pharmaceutical products.
