Szczegóły publikacji
Opis bibliograficzny
Decreased serum zinc concentration during depressive episode in patients with bipolar disorder / Marcin Siwek, Magdalena Sowa-Kućma, Krzysztof Styczeń, Bernadeta Szewczyk, Witold RECZYŃSKI, Paulina Misztak, Roman Topór-Mądry, Gabriel Nowak, Dominika Dudek, Janusz K. Rybakowski // Journal of Affective Disorders ; ISSN 0165-0327. — 2016 — vol. 190, s. 272–277. — Bibliogr. s. 276–277, Abstr. — Publikacja dostępna online od: 2015-12-27. — Witold Reczyński – afiliacja: University of Science and Technology
Autorzy (10)
- Siwek Marcin
- Sowa-Kućma Magdalena
- Styczeń Krzysztof
- Szewczyk Bernadeta
- AGHReczyński Witold
- Misztak Paulina
- Topór-Mądry Roman
- Nowak Gabriel
- Dudek Dominika
- Rybakowski Janusz K.
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 95159 |
|---|---|
| Data dodania do BaDAP | 2016-01-28 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.jad.2015.10.026 |
| Rok publikacji | 2016 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Affective Disorders |
Abstract
Objectives: Zinc may be involved in the pathophysiology and treatment of depressive disorder. However, data on this issue in bipolar disorder (BD) are limited. The aim of the study was to assess zinc concentrations in the blood serum of patients at various phases and stages of bipolar disorder. Methods: The study included 129 patients with a diagnosis of bipolar disorder type I (n=69) or type II (n=60). Fifty-eight were in a depressive episode, 23 in a manic episode and 48 in remission. Fifty healthy volunteers made a control group. Zinc concentration was measured using flame atomic absorption spectrometry. Results: Serum zinc level in patients diagnosed with BD type I in the depressive phase was significantly reduced as compared with mania, remission and healthy subjects. In the BD type II, serum zinc level in hypomania, depression or remission phase was not significantly different from the control group. In the whole group, lower level of zinc in depression compared to remission and control subjects was found during late stage of the illness but not in the early stage. Zinc concentration was not dependent on the severity of manic or depressive symptoms and subtype of depression but correlated positively with the number of manic/hypomanic relapses in the past year. Limitations: Lack of prospective model, heterogeneity of pharmacological treatment, small number of subgroups presenting specified clinical features. Conclusions: Decreased serum zinc concentration occurs in depression in BD type I and probably in depression in the late stage of BD. (C) 2015 Elsevier B.V. All rights reserved.
