Szczegóły publikacji
Opis bibliograficzny
Long-lasting antidepressant-like activity of the GPR39 zinc receptor agonist TC-G 1008 / Gabriela Starowicz, Magdalena Jarosz, Ewelina Frąckiewicz, Natalia Grzechnik, Beata OSTACHOWICZ, Gabriel Nowak, Katarzyna Mlyniec // Journal of Affective Disorders ; ISSN 0165-0327. — 2019 — vol. 245, s. 325–334. — Bibliogr. s. 332–334, Abstr. — Publikacja dostępna online od: 2018-11-02. — N. Grzechnik, K. Młyniec - afiliacja: Jagiellonian University Medical College
Autorzy (7)
- Starowicz Gabriela
- Jarosz Magdalena
- Frąckiewicz Ewelina
- Grzechnik Natalia
- AGHOstachowicz Beata
- Nowak Gabriel
- Młyniec Katarzyna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 120368 |
|---|---|
| Data dodania do BaDAP | 2019-06-04 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.jad.2018.11.003 |
| Rok publikacji | 2019 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Affective Disorders |
Abstract
Background: The discovery of the zinc-sensing receptor, has provided new possibilities for explaining the neurobiology of zinc. Recent studies indicate that the GPR39 zinc receptor may play an important role in the pathogenesis of depression as well as in the antidepressant mechanism of action. Methods: In this study we evaluated the time-course of the antidepressant response of the GPR39 agonist (TC-G 1008), imipramine, ZnCl2 and MK-801 in the forced swim test in mice 30 min, 3 h, 6 h and 24 h after acute drug administration as well as after 14-day treatment. Zinc level was measured in serum of mice. BDNF protein level was evaluated in hippocampus following both acute and chronic TC-G 1008 treatment. Results: A single administration of the GPR39 agonist caused an antidepressant-like effect lasting up to 24 h following the injection, which is longer than the effect of imipramine, ZnCl2 and MK-801. Chronic treatment with these compounds caused a decrease in immobility time in the FST. Serum zinc concentrations showed an increased level following chronic ZnCl2 administration, but not following administration of TC-G 1008, imipramine or MK-801. We also observed some tendencies for increased BDNF following acute TC-G 1008 treatment. Limitations: TC-G 1008 is new drug designed to study GPR39 therefore additional pharmacodynamic and pharmacokinetic properties in preclinical studies are required. Conclusion: This study shows for the first time the long-lasting antidepressant effect of the GPR39 agonist in comparison with imipramine, ZnCl2 and MK-801. Our findings suggest that GPR39 should be considered as a target in efforts to develop new antidepressant drugs.
