Szczegóły publikacji
Opis bibliograficzny
Polyurethane/polylactide-based biomaterials combined with rat olfactory bulb-derived cells and adipose-derived mesenchymal stromal cells for neural regenerative medicine applications / Jakub Grzesiak, Krzysztof Marycz, Dariusz Szarek, Paulina Bednarz, Jadwiga LASKA // Materials Science and Engineering. C, Biomimetic Materials, Sensors and Systems ; ISSN 0928-4931. — 2015 — vol. 52, s. 163–170. — Bibliogr. s. 169–170, Abstr.
Autorzy (5)
- Grzesiak Jakub
- Marycz Krzysztof
- Szarek Dariusz
- Bednarz Paulina
- AGHLaska Jadwiga
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 88655 |
|---|---|
| Data dodania do BaDAP | 2015-04-13 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.msec.2015.03.050 |
| Rok publikacji | 2015 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Materials Science and Engineering, C, Materials for Biological Applications |
Abstract
Research concerning the elaboration and application of biomaterial which may support the nerve tissue regeneration is currently one of the most promising directions. Biocompatible polymer devices are noteworthy group among the numerous types of potentially attractive biomaterials for regenerative medicine application. Polylactides and polyurethanes may be utilized for developing devices for supporting the nerve regeneration, like nerve guide conduits or bridges connecting the endings of broken nerve tracts. Moreover, the combination of these biomaterial-devices with regenerative-cell populations, like stem or precursor cells should significantly improve the final therapeutic effect. Therefore, the composition and structure of final device should support the proper adhesion and growth of cells destined for clinical application. In current research, the three polymer mats elaborated for connecting the broken nerve tracts, made from polylactide, polyurethane and their blend were evaluated both for physical properties and in vitro, using the olfactory-bulb glial cells and mesenchymal stem cells. The evaluation of Young's modulus, wettability and roughness of obtained materials showed the differences between analyzed samples. The analysis of cell adhesion, proliferation and morphology showed that the polyurethane-polylactide blend was the most neutral for cells in culture, while in the pure polymer samples there were significant alterations observed. Our results indicated that polyurethane-polylactide blend is an optimal composition for culturing and delivery of glial and mesenchymal stem cells. (C) 2015 The Authors. Published by Elsevier B.V.