Szczegóły publikacji
Opis bibliograficzny
Polyurethane/polylactide-based electrospun nonwovens as carriers for human adipose-derived stromal stem cells and chondrogenic progenitor cells / Krzysztof Marycz, Monika Marędziak, Jakub Grzesiak, Ryszard Fryczkowski, Jadwiga LASKA // Polymer-Plastics Technology and Engineering ; ISSN 0360-2559. — 2016 — vol. 55 no. 18, s. 1897–1907. — Bibliogr. s. 1906–1907, Abstr. — Publikacja dostępna online od: 2016-06-21
Autorzy (5)
- Marycz Krzysztof
- Marędziak Monika
- Grzesiak Jakub
- Fryczkowski Ryszard
- AGHLaska Jadwiga
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 104467 |
|---|---|
| Data dodania do BaDAP | 2017-03-21 |
| Tekst źródłowy | URL |
| DOI | 10.1080/03602559.2016.1163586 |
| Rok publikacji | 2016 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Polymer-Plastics Technology and Engineering |
Abstract
Articular cartilage dysfunctions are major cause of pain and disability and lead to serious health complications. Cell-based therapies are proposed as treatment methods for cartilage regeneration. In this study, we proposed polyurethane/poly(L-lactide-co-D, L-lactide)-based electrospun nonwovens as carriers for the delivery of human adipose-derived stromal stem cells. We found that 6:4 and 8:2 polyurethane/poly(L-lactide-co-D, L-lactide) initially enhance proliferative rate of human adipose-derived stromal stem cells, shorten their population doubling time, promote creation of functional chondrogenic nodules during chondrogenic differentiation, improve the collagen-2-to-collagen-1 protein ratio, and upregulate the expression of collagen-2 and aggrecan genes.