Szczegóły publikacji
Opis bibliograficzny
Study of Cu chemical state inside single neurons from Parkinson's disease and control substantia nigra using the micro-XANES technique / Joanna CHWIEJ, Dariusz Adamek, Magdalena SZCZERBOWSKA-BORUCHOWSKA, Anna Krygowska-Wajs, Sylvain Bohic, Marek LANKOSZ // Journal of Trace Elements in Medicine and Biology ; ISSN 0946-672X. — 2008 — vol. 22 iss. 3, s. 183–188. — Bibliogr. s. 188, Abstr.
Autorzy (6)
- AGHChwiej Joanna
- Adamek Dariusz
- AGHSzczerbowska-Boruchowska Magdalena
- Krygowska-Wajs Anna
- Bohic Sylvain
- AGHLankosz Marek
Dane bibliometryczne
| ID BaDAP | 43256 |
|---|---|
| Data dodania do BaDAP | 2009-02-05 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.jtemb.2008.03.006 |
| Rok publikacji | 2008 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Trace Elements in Medicine and Biology |
Abstract
Parkinson's disease (PD) is referred to as Idiopathic disorder. which means that its causes have not been found yet. However, a few processes, such is oxidative stress. protein aggregation and mitochondrial dysfunction are suspected to lead to the atrophy and death of substantia nigra (SN) neurons in case of this neurodegenerative disorder. Cu is a trace element whose role In the pathogenesis of PD is widely discussed. The investigation of Cu oxidation state inside single nerve cells from SN of PD and control cases may shed some new light oil the role of this element in PD. The differences in Cu chemical state were investigated with the use of X-ray absorption near edge structure (XANES) spectroscopy. The least-square fitting method was applied For the analysis or XANES spectra. The comparison of the positions of white line multiple scattering and pre-edge peak maximum at the energy scale did not reveal the existence of differences in Cu chemical state between PD and control samples. However, it was found that most of the Cu inside SN neurons occurs in tetrahedral environment and probably its Cu(II).
