Szczegóły publikacji
Opis bibliograficzny
Investigations of differences in iron oxidation state inside single neurons from substantia nigra of Parkinson's disease and control patients using the micro-XANES technique / Joanna CHWIEJ, Dariusz Adamek, Magdalena SZCZERBOWSKA-BORUCHOWSKA, Anna Krygowska-Wajs, Sławomir WÓJCIK, Gerald Falkenberg, Anna MAŃKA, Marek LANKOSZ // Journal of Biological Inorganic Chemistry ; ISSN 0949-8257 . — 2007 — vol. 12 iss. 2, s. 204–211. — Bibliogr. s. 210–211, Abstr. — Publikacja dostępna online od: 2006-11-21
Autorzy (8)
- AGHChwiej Joanna
- Adamek Dariusz
- AGHSzczerbowska-Boruchowska Magdalena
- Krygowska-Wajs Anna
- AGHWójcik Sławomir
- Falkenberg Gerald
- AGHMańka Anna
- AGHLankosz Marek
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 33860 |
|---|---|
| Data dodania do BaDAP | 2007-08-14 |
| Tekst źródłowy | URL |
| DOI | 10.1007/s00775-006-0179-5 |
| Rok publikacji | 2007 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Biological Inorganic Chemistry |
Abstract
X-ray absorption near edge structure spectroscopy was applied in order to investigate differences in iron chemical state between the nerve cells of substantia nigra (SN) representing Parkinson's disease (PD) and those of control cases. Autopsy samples were cut using a cryotome, and were not fixed and not embedded in paraffin. The comparison of the absorption spectra near the iron K-edge measured in melanized neurons from SN of PD and control samples did not show significant differences in iron oxidation state. Measurements of inorganic reference materials containing iron in the second and third oxidation states indicate that most of the iron in all the nerve cell bodies examined was oxidized and occurred as trivalent ferric iron (Fe3+).
