Szczegóły publikacji
Opis bibliograficzny
Keratin-acetate dressing accelerates diabetic wound healing, promotes M2 macrophage polarization and increases cytokeratins 16 and 17 expression – in vitro and in vivo studies / Łukasz Mazurek, Mateusz Rybka, Mikołaj Zajdel, Jan Jurak, Mateusz Szudzik, Anna Laskowska, Joanna Czuwara, Dorota Sulejczak, Szymon SALAGIERSKI, Michał DZIADEK, Antoni Sureda, Robert Schwartz, Marek Konop // Macromolecular Bioscience ; ISSN 1616-5187 . — 2026 — vol. 26 iss. 2, s. 1-16. — Bibliogr. s. 14-16, Abstr. — Publikacja dostępna online od: 2026-02-25
Autorzy (13)
- Mazurek Łukasz
- Rybka Mateusz
- Zajdel Mikołaj
- Jurak Jan
- Szudzik Mateusz
- Laskowska Anna K.
- Czuwara Joanna
- Sulejczak Dorota
- AGHSalagierski Szymon
- AGHDziadek Michał
- Sureda Antoni
- Schwartz Robert A.
- Konop Marta
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 166700 |
|---|---|
| Data dodania do BaDAP | 2026-03-27 |
| Tekst źródłowy | URL |
| DOI | 10.1002/mabi.202500351 |
| Rok publikacji | 2026 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Macromolecular Bioscience |
Abstract
A novel keratin-based wound dressing enriched with sodium acetate (FKDP+0.1%Act) was developed to address the constant challenges of chronic wound healing in diabetes. By combining bioactive keratin fibers with the anti-inflammatory properties of acetate, this study explored the material's regenerative and immunomodulatory potential using in vitro models of keratinocytes and macrophages, alongside full-thickness wounds in diabetic rats. FKDP+0.1%Act markedly accelerated wound closure and improved tissue architecture during early healing. It promoted a shift toward pro-regenerative M2 macrophage polarization, reduced M1-associated markers and tumor necrosis factor α (TNFα) expression, and significantly upregulated vascular endothelial growth factor (VEGF) and cytokeratins 16 and 17 (KRT16/17) - key angiogenesis and epidermal repair mediators. These effects were consistently observed across in vivo and in vitro methods, highlighting a synergistic interaction between keratin and acetate. The dressing preserved structural integrity, demonstrated favorable cytocompatibility, and modulated key inflammatory and regenerative pathways. These findings underscore the translational potential of FKDP+0.1%Act as a dual-functional biomaterial capable of enhancing epithelial regeneration and reprogramming inflammatory responses in impaired diabetic wound environments.
