Szczegóły publikacji
Opis bibliograficzny
Air-dried vs. freeze-dried chitosan-based matrices: effect of drying techniques on the physicochemical and biological properties of biomaterials for regenerative medicine / Paulina Kazimierczak, Vladyslav Vivcharenko, Aleksandra BENKO, Grzegorz Kalisz, Mateusz MARZEC, Liudmyla Nosach, Anna Sroka-Bartnicka, Joanna Wessely-Szponder, Agata Przekora // International Journal of Biological Macromolecules ; ISSN 0141-8130 . — 2026 — vol. 338 pt. 2 art. no. 149826, s. 1–16. — Bibliogr. s. 14–16, Abstr. — Publikacja dostępna online od: 2025-12-21
Autorzy (9)
- Kazimierczak Paulina
- Vivcharenko Vladyslav
- AGHBenko Aleksandra
- Kalisz Grzegorz
- AGHMarzec Mateusz M.
- Nosach Liudmyla
- Sroka-Bartnicka Anna
- Wessely-Szponder Joanna
- Przekora Agata
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 165692 |
|---|---|
| Data dodania do BaDAP | 2026-02-25 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.ijbiomac.2025.149826 |
| Rok publikacji | 2026 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | International Journal of Biological Macromolecules |
Abstract
The aim of this study was to comprehensively evaluate the effects of two main drying techniques – air-drying and freeze-drying – on the physicochemical and biological properties of chitosan-based matrices (chitosan/curdlan and chitosan/agarose) in order to identify the drying method that is more favorable to cell adhesion and proliferation. Freeze-dried matrices exhibited a highly porous, foam-like microstructure with significantly higher surface roughness (Sa: 24.6–50.3 μm) compared to thin, smooth air-dried films (Sa: 2.5–9.9 μm). Water contact angle analysis of rehydrated samples revealed superhydrophilicity in freeze-dried matrices (∼31.4° or undetectable), whereas air-dried matrices remained moderately hydrophilic (54.4–73.6°). Surface chemistry analysis indicated higher amounts of polar species in freeze-dried samples. Both matrices showed gradual biodegradation over time. Protein adsorption analysis revealed that freeze-dried matrices adsorbed significantly more proteins from blood plasma than air-dried matrices. Unexpectedly, freeze-dried matrices hindered cell adhesion and proliferation, in contrast to air-dried matrices. These findings demonstrate that drying conditions can critically determine not only physicochemical properties but also biological performance. This knowledge provides a practical framework for tailoring chitosan-based biomaterials either to support cell growth in regenerative scaffolds or to suppress cell colonization in wound dressings and temporary implants.
