Szczegóły publikacji
Opis bibliograficzny
The role of glycerol in manufacturing freeze-dried chitosan and cellulose foams for mechanically stable scaffolds in skin tissue engineering / Katarína Verčimáková, Joanna KARBOWNICZEK, Marian Sedlář, Urszula STACHEWICZ, Lucy Vojtová // International Journal of Biological Macromolecules ; ISSN 0141-8130. — 2024 — vol. 275 Pt. 1 art. no. 133602, s. 1–12. — Bibliogr. s. 10–12, Abstr. — Publikacja dostępna online od: 2024-07-02
Autorzy (5)
- Verčimáková Katarína
- AGHKarbowniczek Joanna
- Sedlář Marian
- AGHStachewicz Urszula
- Vojtová Lucy
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 154551 |
|---|---|
| Data dodania do BaDAP | 2024-07-19 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.ijbiomac.2024.133602 |
| Rok publikacji | 2024 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | International Journal of Biological Macromolecules |
Abstract
Various strategies have extensively explored enhancing the physical and biological properties of chitosan and cellulose scaffolds for skin tissue engineering. This study presents a straightforward method involving the addition of glycerol into highly porous structures of two polysaccharide complexes: chitosan/carboxymethyl cellulose (Chit/CMC) and chitosan/oxidized cellulose (Chit/OC); during a one-step freeze-drying process. Adding glycerol, especially to Chit/CMC, significantly increased stability, prevented degradation, and improved mechanical strength by nearly 50%. Importantly, after 21 days of incubation in enzymatic medium Chit/CMC scaffold has almost completely decomposed, while foams reinforced with glycerol exhibited only 40% mass loss. It is possible due to differences in multivalent cations and polymer chain contraction, resulting in varied hydrogen bonding and, consequently, distinct physicochemical outcomes. Additionally, the scaffolds with glycerol improved the cellular activities resulting in over 40% higher proliferation of fibroblast after 21 days of incubation. It was achieved by imparting water resistance to the highly absorbent material and aiding in achieving a balance between hydrophilic and hydrophobic properties. This study clearly indicates the possible elimination of additional crosslinkers and multiple fabrication steps that can reduce the cost of scaffold production for skin tissue engineering applications while tailoring mechanical strength and degradation.
