Szczegóły publikacji
Opis bibliograficzny
Antioxidant and UV-protective evaluation of tocochromanols in nanoformulations / Ewa OLBIŃSKA, Aleksandra ORZECHOWSKA, Jerzy Kruk, Renata SZYMAŃSKA // International Journal of Pharmaceutics ; ISSN 0378-5173 . — 2025 — vol. 686 art. no. 126308, s. 1–10. — Bibliogr. s. 8–10, Abstr. — Publikacja dostępna online od: 2025-10-26
Autorzy (4)
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 164195 |
|---|---|
| Data dodania do BaDAP | 2025-12-06 |
| DOI | 10.1016/j.ijpharm.2025.126308 |
| Rok publikacji | 2025 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | International Journal of Pharmaceutics |
Abstract
Tocochromanols, a group of compounds widely present in plant oils and commonly used in cosmetic formulations, exhibit varying photostability under UV irradiation. In this study, we investigated the photostability and potential UV-protective properties of several tocochromanol homologues (α-tocopherol, γ-tocopherol, γ-tocotrienol and plastochromanol-8) both in free form and encapsulated within liposomal and niosomal carriers. Our findings demonstrated that α-tocopherol, despite its widespread use in sunscreens, was the least stable under UV exposure. In contrast, γ-tocopherol, γ-tocotrienol and plastochromanol-8 showed significantly higher stability, particularly when encapsulated in liposomes, maintaining antioxidant activity even after prolonged UV irradiation. HPLC analysis confirmed a pronounced degradation of α-tocopherol upon UV exposure, while other homologues were less affected. Furthermore, encapsulation enhanced the calculated SPF values, with the highest protection observed for γ-tocopherol and plastochromanol-8 in liposomes. These results suggest that non-α- tocochromanol forms offer promising potential as effective and stable components in UV-protective formulations. This research highlights the importance of further exploring the diverse roles of tocochromanols in photoprotection, especially given their natural abundance in plant-derived cosmetic ingredients.
