Szczegóły publikacji
Opis bibliograficzny
Antioxidant and neuroprotective activity of vitamin E homologues: in vitro study / Agnieszka TRELA-MAKOWEJ, Monika Leśkiewicz, Jerzy Kruk, Andrzej ̇Ządło, Agnieszka Basta-Kaim, Renata SZYMAŃSKA // Metabolites [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 2218-1989. — 2022 — vol. 12 iss. 7 art. no. 608, s. 1-20. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 17-20, Abstr. — Publikacja dostępna online od: 2022-06-30
Autorzy (6)
- AGHTrela-Makowej Agnieszka
- Leśkiewicz Monika
- Kruk Jerzy
- Żądło Andrzej
- Basta-Kaim Agnieszka
- AGHSzymańska Renata
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 140963 |
|---|---|
| Data dodania do BaDAP | 2022-07-13 |
| Tekst źródłowy | URL |
| DOI | 10.3390/metabo12070608 |
| Rok publikacji | 2022 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Metabolites |
Abstract
Here we present comparative data on the inhibition of lipid peroxidation by a variety of tocochromanols in liposomes. We also show for the first time the potential neuroprotective role of all the vitamin E homologues investigated on the neuronally differentiated human neuroblastoma SH-SY5Y cell line. α-Tocopherol had nearly no effect in the inhibition of lipid peroxidation, while β-, γ-, and δ-tocopherols inhibited the reaction completely when it was initiated in a lipid phase. Similar effects were observed for tocotrienol homologues. Moreover, in this respect plastochromanol-8 was as effective as β-, γ-, and δ-tocochromanols. When the prenyllipids were investigated in a 1,1-diphenyl-2-picrylhydrazyl (DPPH) test and incorporated into different lipid carriers, the radical oxidation was most pronounced in liposomes, followed by mixed micelles and the micellar system. When the reaction of tocochromanols was examined in niosomes, the oxidation was most pronounced for α-tocopherol and plastochromanol-8, followed by α-tocotrienol. Next, using retinoic acid-differentiated SH-SY5Y cells, we tested the protective effects of the compounds investigated on hydrogen peroxide (H2O2)-induced cell damage. We showed that tocotrienols were more active than tocopherols in the oxidative stress model. Plastochromanol-8 had a strong inhibitory effect on H2O2-induced lactate dehydrogenase (LDH) release and H2O2-induced decrease in cell viability. The water-soluble α-tocopherol phosphate had neuroprotective effects at all the concentrations analyzed. The results clearly indicate that structural differences between vitamin E homologues reflect their different biological activity and indicate their potential application in pharmacological treatments for neurodegenerative diseases. In this respect, the application of optimal tocochromanol-carrying structures might be critical.
