Szczegóły publikacji
Opis bibliograficzny
Surface-modified ceramic boron carbide as a platform for specific targeting in tumour environments / Dawid KOZIEŃ, Karolina Krygowska, Paulina Żeliszewska, Agnieszka Szczygieł, Anna Rudawska, Bożena Szermer-Olearnik, Piotr RUSINIAK, Katarzyna WĄTOR, Katarzyna Węgierek-Ciura, Piotr JELEŃ, Jakub MARCHEWKA, Katarzyna PASIUT, Janusz PARTYKA, Elżbieta Pajtasz-Piasecka, Zbigniew PĘDZICH // Applied Sciences (Basel) [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 2076-3417. — 2025 — vol. 15 iss. 5 art. no. 2734, s. 1–15. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 14–15, Abstr. — Publikacja dostępna online od: 2025-03-04
Autorzy (15)
- AGHKozień Dawid
- AGHKrygowska Karolina
- Żeliszewska Paulina
- Szczygieł Agnieszka
- Rudawska Anna
- Szermer-Olearnik Bożena
- AGHRusiniak Piotr
- AGHWątor Katarzyna
- Węgierek-Ciura Katarzyna
- AGHJeleń Piotr
- AGHMarchewka Jakub
- AGHPasiut Katarzyna
- AGHPartyka Janusz
- Pajtasz-Piasecka Elżbieta
- AGHPędzich Zbigniew
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 158914 |
|---|---|
| Data dodania do BaDAP | 2025-04-22 |
| Tekst źródłowy | URL |
| DOI | 10.3390/app15052734 |
| Rok publikacji | 2025 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Applied Sciences (Basel) |
Abstract
Boron Neutron Capture Therapy (BNCT) is a therapeutic approach used to treat malignancies that are difficult to localise and typically inoperable. This therapy involves two stages: the administration of the boron (10B) isotope, which selectively enters cancer cells without affecting healthy tissue, followed by irradiation of the tumour with a neutron beam. In this study, boron carbide (B4C), a ceramic material with exceptional physical and chemical properties, was used as a nanoparticle platform for BNCT. The surface of the boron carbide nanoparticles was optimised by modifying them with compounds such as dextrin, dextran T70, sorbitol, lysine, and arginine. Boron carbide was synthesised directly from boron and carbon and then subjected to grinding, washing, and centrifugation. The unmodified and modified samples were analysed for their particle size, zeta potential, and toxicity against glioblastoma T98G cells. Additionally, FTIR spectroscopy confirmed the successful surface modifications. The results demonstrate that boron carbide, as a ceramic material, can be effectively functionalised with biocompatible compounds. Among the tested modifications, B4C-dextrin and B4C-dextran T70 exhibited the highest toxicity towards cancer cells, demonstrating the potential of ceramic platforms in biomedical applications.
