Szczegóły publikacji

Opis bibliograficzny

Synthesis and characterization of boron carbide nanoparticles as potential boron-rich therapeutic carriers / Dawid KOZIEŃ, Paulina Żeliszewska, Bożena Szermer-Olearnik, Zbigniew Adamczyk, Anna Wróblewska, Agnieszka Szczygieł, Katarzyna Węgierek-Ciura, Jagoda Mierzejewska, Elżbieta Pajtasz-Piasecka, Tomasz TOKARSKI, Grzegorz CIOS, Stanisław Cudziło, Zbigniew PĘDZICH // Materials [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1996-1944. — 2023 — vol. 16 iss. 19 art. no. 6534, s. 1–17. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 15–17, Abstr. — Publikacja dostępna online od: 2023-10-02

Autorzy (13)

Słowa kluczowe

boron neutron capture therapyboron carbideBNCTnano powders

Dane bibliometryczne

ID BaDAP149078
Data dodania do BaDAP2023-10-09
Tekst źródłowyURL
DOI10.3390/ma16196534
Rok publikacji2023
Typ publikacjiartykuł w czasopiśmie
Otwarty dostęptak
Creative Commons
Czasopismo/seriaMaterials

Abstract

Boron carbide is one of the hardest materials in the world which can be synthesized by various methods. The most common one is a carbothermic or magnesiothermic reduction of B2O3 performed at high temperatures, where the obtained powder still requires grinding and purification. The goal of this research is to present the possibility of synthesizing B4C nanoparticles from elements via vapor deposition and modifying the morphology of the obtained powders, particularly those synthesized at high temperatures. B4C nanoparticles were synthesized in the process of direct synthesis from boron and carbon powders heated at the temperature of 1650 ◦C for 2 h under argon and characterized by using scanning electron microscopy, transmission electron microscopy, atomic force microscopy, X-ray diffraction analysis, and dynamic light scattering measurements. The physicochemical characteristics of B4C nanoparticles were determined, including the diffusion coefficients, hydrodynamic diameter, electrophoretic mobilities, and zeta potentials. An evaluation of the obtained B4C nanoparticles was performed on several human and mouse cell lines, showing the relation between the cytotoxicity effect and the size of the synthesized nanoparticles. Assessing the suitability of the synthesized B4C for further modifications in terms of its applicability in boron neutron capture therapy was the overarching goal of this research.

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