Szczegóły publikacji
Opis bibliograficzny
Macrophages as carriers of boron carbide nanoparticles dedicated to boron neutron capture therapy / Anna Wróblewska, Bożena Szermer-Olearnik, Agnieszka Szczygieł, Katarzyna Węgierek-Ciura, Jagoda Mierzejewska, Dawid KOZIEŃ, Paulina Żeliszewska, Roksana Kruszakin, Paweł Migdał, Zbigniew PĘDZICH, Elżbieta Pajtasz-Piasecka // Journal of Nanobiotechnology [Dokument elektroniczny]. - Czasopismo elektroniczne ; ISSN 1477-3155. — 2024 — vol. 22 art. no. 183, s. 1–14. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 14, Abstr. — Publikacja dostępna online od: 2024-04-15
Autorzy (11)
- Wróblewska Anna
- Szermer-Olearnik Bożena
- Szczygieł Agnieszka
- Węgierek-Ciura Katarzyna
- Mierzejewska Jagoda
- AGHKozień Dawid
- Żeliszewska Paulina
- Kruszakin Roksana
- Migdał Paweł
- AGHPędzich Zbigniew
- Pajtasz-Piasecka Elżbieta
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 152819 |
|---|---|
| Data dodania do BaDAP | 2024-05-14 |
| Tekst źródłowy | URL |
| DOI | 10.1186/s12951-024-02397-5 |
| Rok publikacji | 2024 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Journal of Nanobiotechnology |
Abstract
Background The use of cells as carriers for the delivery of nanoparticles is a promising approach in anticancer therapy, mainly due to their natural properties, such as biocompatibility and non-immunogenicity. Cellular carriers prevent the rapid degradation of nanoparticles, improve their distribution, reduce cytotoxicity and ensure selective delivery to the tumor microenvironment. Therefore, we propose the use of phagocytic cells as boron carbide nanoparticle carriers for boron delivery to the tumor microenvironment in boron neutron capture therapy. Results Macrophages originating from cell lines and bone marrow showed a greater ability to interact with boron carbide (B4C) than dendritic cells, especially the preparation containing larger nanoparticles (B4C 2). Consequently, B4C 2 caused greater toxicity and induced the secretion of pro-inflammatory cytokines by these cells. However, migration assays demonstrated that macrophages loaded with B4C 1 migrated more efficiently than with B4C 2. Therefore, smaller nanoparticles (B4C 1) with lower toxicity but similar ability to activate macrophages proved to be more attractive. Conclusions Macrophages could be promising cellular carriers for boron carbide nanoparticle delivery, especially B4C 1 to the tumor microenvironment and thus prospective use in boron neutron capture therapy.
