Szczegóły publikacji
Opis bibliograficzny
Vibrational spectroscopy methods for investigation of the animal models of glioblastoma multiforme / Karolina OLBRICH, Zuzanna Setkowicz, Kamil KAWOŃ, Mateusz Czyżycki, Natalia Janik-Olchawa, Ilaria Carlomagno, Giuliana Aquilanti, Joanna CHWIEJ // Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy ; ISSN 1386-1425. — 2023 — vol. 303 art. no. 123230, s. 1-17. — Bibliogr. s. 15-17, Abstr. — Publikacja dostępna online od: 2023-08-02. — M. Czyżycki – afiliacja: Institute for Photon Science and Synchrotron Radiation, Karlsruhe Institute of Technology, Germany
Autorzy (8)
- AGHOlbrich Karolina L.
- Setkowicz Zuzanna
- AGHKawoń Kamil
- Czyżycki Mateusz
- Janik-Olchawa Natalia
- Carlomagno Ilaria
- Aquilanti Giuliana
- AGHChwiej Joanna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 148430 |
|---|---|
| Data dodania do BaDAP | 2023-09-21 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.saa.2023.123230 |
| Rok publikacji | 2023 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Spectrochimica Acta, Part A, Molecular and Biomolecular Spectroscopy |
Abstract
Glioblastoma multiforme (GBM) is the most common and devastating primary brain tumor among adults. It is highly lethal disease, as only 25% of patients survive longer than 1 year and only 5% more than 5 years from the diagnosis. To search for the new, more effective methods of treatment, the understanding of mechanisms underlying the process of tumorigenesis is needed. The new light on this problem may be shed by the analysis of biochemical anomalies of tissues affected by tumor growth. Therefore, in the present work, we applied the Fourier transform infrared (FTIR) and Raman microspectroscopy to evaluate changes in the distribution and structure of biomolecules appearing in the rat brain as a result of glioblastoma development. In turn, synchrotron X-ray fluorescence microscopy was utilized to determine the elemental anomalies appearing in the nervous tissue. To achieve the assumed goals of the study animal models of GBM were used. The rats were subjected to the intracranial implantation of glioma cells with different degree of invasiveness. For spectroscopic investigation brain slices taken from the area of cancer cells administration were used. The obtained results revealed, among others, the decrease content of lipids and compounds containing carbonyl groups, compositional and structural changes of proteins as well as abnormalities in the distribution of low atomic number elements within the region of tumor.
