Szczegóły publikacji
Opis bibliograficzny
The methods of vibrational microspectroscopy reveals long-term biochemical anomalies within the region of mechanical injury within the rat brain / Kamil KAWOŃ, Zuzanna Setkowicz, Agnieszka DRÓŻDŻ, Krzysztof Janeczko, Joanna CHWIEJ // Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy ; ISSN 1386-1425. — 2021 — vol. 263 art. no. 120214, s. 1-9. — Bibliogr. s. 8-9, Abstr. — Publikacja dostępna online od: 2021-07-22
Autorzy (5)
- AGHKawoń Kamil
- Setkowicz-Janeczko Zuzanna
- AGHDróżdż Agnieszka
- Janeczko Krzysztof
- AGHChwiej Joanna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 136062 |
|---|---|
| Data dodania do BaDAP | 2021-09-07 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.saa.2021.120214 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Spectrochimica Acta, Part A, Molecular and Biomolecular Spectroscopy |
Abstract
Traumatic brain injury (TBI), meaning functional or structural brain damage which appear as a result of the application of the external physical force, constitutes the main cause of death and disability of individuals and a great socioeconomic problem. To search for the new therapeutic strategies for TBI, better knowledge about posttraumatic pathological changes occurring in the brain is necessary. Therefore in the present paper the Fourier transform infrared microspectroscopy and Raman microscopy were used to examine local and remote biochemical changes occurring in the rat brain as a result of focal cortex injury. The site of the injury and the dorsal part of the hippocampal formation together with the above situated cortex and white matter were the subject of the study. The topographic and quantitative biochemical analysis followed with the statistical study using principal component analysis showed significant biomolecular anomalies within the lesion site but not in the area of the dorsal hippocampal formation and in the above situated white matter and cortex. The observed intralesional anomalies included significantly decreased accumulation of lipids and their structural changes within the place of injury. Also the levels of compounds containing phosphate and carbonyl groups were lower within the lesion site comparing to the surrounding cortex. The opposite relation was, in turn, found for the bands characteristic to proteins and cholesterol/cholesterol esters.
