Szczegóły publikacji
Opis bibliograficzny
Gold nanoparticles inhibit extravasation of canine osteosarcoma cells in the ex ovo chicken embryo chorioallantoic membrane model / Anna Małek, Marek WOJNICKI, Aleksandra Borkowska, Michał Wójcik, Gabriela Ziółek, Roman Lechowski, Katarzyna Zabielska-Koczywąs // International Journal of Molecular Sciences [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1422-0067. — 2023 — vol. 24 iss. 12 art. no. 9858, s. 1-19. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 17-19, Abstr. — Publikacja dostępna online od: 2023-06-07
Autorzy (7)
- Małek Anna
- AGHWojnicki Marek
- Borkowska Aleksandra
- Wójcik Michał
- Ziółek Gabriela
- Lechowski Roman
- Zabielska-Koczywąs Katarzyna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 147196 |
|---|---|
| Data dodania do BaDAP | 2023-07-14 |
| Tekst źródłowy | URL |
| DOI | 10.3390/ijms24129858 |
| Rok publikacji | 2023 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | International Journal of Molecular Sciences |
Abstract
Canine osteosarcoma (OS) is an aggressive bone tumor with high metastatic potential and poor prognosis, mainly due to metastatic disease. Nanomedicine-based agents can be used to improve both primary and metastatic tumor treatment. Recently, gold nanoparticles were shown to inhibit different stages of the metastatic cascade in various human cancers. Here, we assessed the potential inhibitory effect of the glutathione-stabilized gold nanoparticles (Au-GSH NPs) on canine OS cells extravasation, utilizing the ex ovo chick embryo chorioallantoic membrane (CAM) model. The calculation of cells extravasation rates was performed using wide-field fluorescent microscopy. Transmission electron microscopy and Microwave Plasma Atomic Emission Spectroscopy revealed Au-GSH NPs absorption by OS cells. We demonstrated that Au-GSH NPs are non-toxic and significantly inhibit canine OS cells extravasation rates, regardless of their aggressiveness phenotype. The results indicate that Au-GSH NPs can act as a possible anti metastatic agent for OS treatment. Furthermore, the implemented CAM model may be used as a valuable preclinical platform in veterinary medicine, such as testing anti-metastatic agents.
