Szczegóły publikacji
Opis bibliograficzny
Aerogels based on cationically modified chitosan and poly(vinyl alcohol) for efficient capturing of viruses / Dorota LACHOWICZ, Angelika KMITA, Roma WIRECKA, Katarzyna BERENT, Michał SZUWARZYŃSKI, Szczepan ZAPOTOCZNY, Anna Pajdak, Grzegorz CIOS, Natalia Mazur-Panasiuk, Krzysztof Pyrc, Andrzej BERNASIK // Carbohydrate Polymers ; ISSN 0144-8617. — 2023 — vol. 312 art. no. 120756, s. 1–12. — Bibliogr. s. 11–12, Abstr. — Publikacja dostępna online od: 2023-03-02. — R. Wirecka, A. Bernasik - dod. afiliacja: ACMiN. — Sz. Zapotoczny - dod. afiliacja: Faculty of Chemistry, Jagiellonian University
Autorzy (11)
- AGHLachowicz Dorota
- AGHKmita Angelika
- AGHWirecka Roma
- AGHBerent Katarzyna
- AGHSzuwarzyński Michał
- AGHZapotoczny Szczepan
- Pajdak Anna
- AGHCios Grzegorz
- Mazur-Panasiuk Natalia
- Pyrc Krzysztof
- AGHBernasik Andrzej
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 146544 |
|---|---|
| Data dodania do BaDAP | 2023-05-22 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.carbpol.2023.120756 |
| Rok publikacji | 2023 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Carbohydrate Polymers |
Abstract
In this study, we developed a new filtering bioaerogel based on linear polyvinyl alcohol (PVA) and the cationic derivative of chitosan (N-[(2-hydroxy-3-trimethylamine) propyl] chitosan chloride, HTCC) with a potential antiviral application. A strong intermolecular network architecture was formed thanks to the introduction of linear PVA chains, which can efficiently interpenetrate the glutaraldehyde(GA)-crosslinked HTCC chains. The morphology of the obtained structures was examined using scanning electron microscopy (SEM) and atomic force microscopy (AFM). The aerogels and modified polymers' elemental composition (including the chemical environment) was determined using X-ray photoelectron spectroscopy (XPS). New aerogels with more than twice as much developed micro-and mesopore space and BET-specific surface area were obtained concerning the starting sample chitosan aerogel crosslinked by glutaraldehyde (Chit/GA). The results obtained from the XPS analysis showed the presence of cationic 3-trimethylammonium groups on the surface of the aerogel, which can interact with viral capsid proteins. No cytotoxic effect of HTCC/GA/PVA aerogel was also observed on fibroblast cells of the NIH3T3 line. Furthermore, the HTCC/GA/PVA aerogel has been shown that efficiently traps mouse hepatitis virus (MHV) from suspension. The presented concept of aerogel filters for virus capture based on modified chitosan and polyvinyl alcohol has a high application potential.