Szczegóły publikacji
Opis bibliograficzny
Acoustic force elastography microscopy / Hsiao-Chuan Liu, Bipin Gaihre, Piotr KIJANKA, Lichun Lu, Matthew W. Urban // IEEE Transactions on Biomedical Engineering ; ISSN 0018-9294. — 2023 — vol. 70 no. 3, s. 841–852. — Bibliogr. s. 851–852, Abstr. — Publikacja dostępna online od: 2022-09-01
Autorzy (5)
- Liu Hsiao-Chuan
- Gaihre Bipin
- AGHKijanka Piotr
- Lu Lichun
- Urban Matthew W.
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 145401 |
|---|---|
| Data dodania do BaDAP | 2023-03-03 |
| Tekst źródłowy | URL |
| DOI | 10.1109/TBME.2022.3203435 |
| Rok publikacji | 2023 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | IEEE Transactions on Biomedical Engineering |
Abstract
Objective: Hydrogel scaffolds have attracted attention to develop cellular therapy and tissue engineering platforms for regenerative medicine applications. Among factors, local mechanical properties of scaffolds drive the functionalities of cell niche. Dynamic mechanical analysis (DMA), the standard method to characterize mechanical properties of hydrogels, restricts development in tissue engineering because the measurement provides a single elasticity value for the sample, requires direct contact, and represents a destructive evaluation preventing longitudinal studies on the same sample. We propose a novel technique, acoustic force elastography microscopy (AFEM), to evaluate elastic properties of tissue engineering scaffolds. Results: AFEM can resolve localized and two-dimensional (2D) elastic properties of both transparent and opaque materials with advantages of being non-contact and non-destructive. Gelatin hydrogels, neat synthetic oligo[poly(ethylene glycol)fumarate] (OPF) scaffolds, OPF hydroxyapatite nanocomposite scaffolds and ex vivo biological tissue were examined with AFEM to evaluate the elastic modulus. These measurements of Young's modulus range from approximately 2 kPa to over 100 kPa were evaluated and are in good agreement with finite element simulations, surface wave measurements, and DMA tests. Conclusion: The AFEM can resolve localized and 2D elastic properties of hydrogels, scaffolds and thin biological tissues. These materials can either be transparent or non-transparent and their evaluation can be done in a non-contact and non-destructive manner, thereby facilitating longitudinal evaluation. Significance: AFEM is a promising technique to quantify elastic properties of scaffolds for tissue engineering and will be applied to provide new insights for exploring elastic changes of cell-laden scaffolds for tissue engineering and material science.
