Szczegóły publikacji
Opis bibliograficzny
In vitro cytotoxicity of biodegradable Zn-Mg surgical wires in tumor and healthy cells / Andrij MILENIN, Krzysztof Łukowicz, Karolina Truchan, Anna Maria Osyczka // Acta of Bioengineering and Biomechanics ; ISSN 1509-409X. — 2021 — vol. 23 no. 4, s. 85–93. — Bibliogr. s. 92–93
Autorzy (4)
- AGHMilenin Andriy
- Łukowicz Krzysztof
- Truchan Karolina
- Osyczka Anna Maria
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 139286 |
|---|---|
| Data dodania do BaDAP | 2022-02-28 |
| Tekst źródłowy | URL |
| DOI | 10.37190/ABB-01927-2021-01 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Acta of Bioengineering and Biomechanics |
Abstract
In this work, we examined the in vitro cytotoxicity of new biodegradable surgical wires. The wires made of zinc with the addition of a small amount of magnesium (pure zinc, ZnMg 0.0026, ZnMg 0.0068, and ZnMg 0.08) have been investigated. The wires were pro- duced using a technology based on extrusion and subsequent drawing. The resulting wires with a diameter of 0.8–1.0 mm are designed to be used in surgical operations related to bone joints. For cytotoxicity studies, we have selected human dental pulp stem cells (hDPSC) as the cell population representing normal osteoprogenitor cells. Considering that, after bone surgeries, the chance of osteosarcoma in- creases, we have compared the results obtained in hDPSC to those obtained with Saos-2 human osteosarcoma cell line. Cultured cells were exposed to the extracts obtained from the materials incubated in culture medium for 24 h with and without preincubation. Extracts of different ratios were examined. The results showed that the extracts obtained from wires made of ZnMg 0.0026 alloy exhibit high toxicity to Saos-2 osteosarcoma cells and low toxicity to hDPSC cells. This was in contrast to all reference materials, i.e., commercial surgical sutures made of steel and polymers, that did not display cytotoxicity toward osteosarcoma cells. Thus, the detected phenomenon for the ZnMg 0.0026 alloy can become the basis for creating biodegradable Zn-Mg surgical wires with antitumor activity.
