Szczegóły publikacji
Opis bibliograficzny
Modification of heat-induced whey protein isolate hydrogel with highly bioactive glass particles results in promising biomaterial for bone tissue engineering / Michał DZIADEK, Katarzyna Charuza, Radmila Kudlackova, Jenny Aveyard, Raechelle D’Sa, Andrada Serafim, Izabela-Cristina Stancu, Horia Iovu, Jemma G. Kerns, Sarah Allinson, Kinga Dziadek, Piotr SZATKOWSKI, Katarzyna CHOLEWA-KOWALSKA, Lucie Bacakova, Elżbieta PAMUŁA, Timothy E. L. Douglas // Materials and Design ; ISSN 0264-1275. — Tytuł poprz.: Materials in Engineering ; ISSN: 0261-3069. — 2021 — vol. 205 art. no. 109749, s. 1–14. — Bibliogr. s. 13–14, Abstr. — Publikacja dostępna online od: 2021-04-20. — M. Dziadek - dod. afiliacje: Jagiellonian University; Lancaster University, United Kingdom
Autorzy (16)
- AGHDziadek Michał
- AGHCharuza Katarzyna
- Kudlackova Radmila
- Aveyard Jenny
- D'Sa Raechelle
- Serafim Andrada
- Stancu Izabela-Cristina
- Iovu Horia
- Kerns Jemma G.
- Allinson Sarah L.
- Dziadek Kinga
- AGHSzatkowski Piotr
- AGHCholewa-Kowalska Katarzyna
- Bačáková Lucie
- AGHPamuła Elżbieta
- Douglas Timothy E. L.
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 134025 |
|---|---|
| Data dodania do BaDAP | 2021-05-11 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.matdes.2021.109749 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Materials & Design |
Abstract
This study deals with the design and comprehensive evaluation of novel hydrogels based on whey protein isolate (WPI) for tissue regeneration. So far, WPI has been considered mainly as a food industry by-product and there are very few reports on the application of WPI in tissue engineering (TE). In this work, WPI-based hydrogels were modified with bioactive glass (BG), which is commonly used as a bone substitute material. Ready-to-use, sterile hydrogels were produced by a simple technique, namely heat-induced gelation. Two different concentrations (10 and 20% w/w) of sol–gel-derived BG particles of two different sizes (2.5 and <45 µm) were compared. µCT analysis showed that hydrogels were highly porous with almost 100% pore interconnectivity. BG particles were generally homogenously distributed in the hydrogel matrix, affecting pore size, and reducing material porosity. Thermal analysis showed that the presence of BG particles in WPI matrix reduced water content in hydrogels and improved their thermal stability. BG particles decreased enzymatic degradation of the materials. The materials underwent mineralization in simulated biological fluids (PBS and SBF) and possessed high radical scavenging capacity. In vitro tests indicated that hydrogels were cytocompatible and supported MG-63 osteoblastic cell functions.
