Szczegóły publikacji
Opis bibliograficzny
Electrospun PCL patches with controlled fiber morphology and mechanical performance for skin moisturization via long-term release of hemp oil for atopic dermatitis / Sara METWALLY, Daniel P. URA, Zuzanna J. KRYSIAK, Łukasz KANIUK, Piotr K. SZEWCZYK, Urszula STACHEWICZ // Membranes [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 2077-0375. — 2021 — vol. 11 iss. 1 art. no. 26, s. 1–13. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 11–13, Abstr. — Publikacja dostępna online od: 2020-12-31
Autorzy (6)
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 132043 |
|---|---|
| Data dodania do BaDAP | 2021-01-11 |
| Tekst źródłowy | URL |
| DOI | 10.3390/membranes11010026 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Membranes |
Abstract
Atopic dermatitis (AD) is a chronic, inflammatory skin condition, caused by wide genetic, environmental, or immunologic factors. AD is very common in children but can occur at any age. The lack of long-term treatments forces the development of new strategies for skin regeneration. Polycaprolactone (PCL) is a well-developed, tissue-compatible biomaterial showing also good mechanical properties. In our study, we designed the electrospun PCL patches with controlled architecture and topography for long-term release in time. Hemp oil shows anti-inflammatory and antibacterial properties, increasing also the skin moisture without clogging the pores. It can be used as an alternative cure for patients that do not respond to traditional treatments. In the study, we tested the mechanical properties of PCL fibers, and the hemp oil spreading together with the release in time measured on skin model and human skin. The PCL membranes are suitable material as patches or bandages, characterized by good mechanical properties and high permeability. Importantly, PCL patches showed release of hemp oil up to 55% within 6 h, increasing also the skin moisture up to 25%. Our results confirmed that electrospun PCL patches are great material as oil carriers indicating a high potential to be used as skin patches for AD skin treatment.
