Szczegóły publikacji
Opis bibliograficzny
Polylactide/hydroxyapatite nonwovens incorporated into chitosan/graphene materials hydrogels to form novel hierarchical scaffolds / Karolina KOSOWSKA, Patrycja DOMALIK-PYZIK, Małgorzata KROK-BORKOWICZ, Jan CHŁOPEK // International Journal of Molecular Sciences [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1422-0067. — 2020 — vol. 21 iss. 7 art. no. 2330, s. 1–13. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 11–13, Abstr. — Publikacja dostępna online od: 2020-03-27
Autorzy (4)
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Dane bibliometryczne
| ID BaDAP | 128376 |
|---|---|
| Data dodania do BaDAP | 2020-05-06 |
| Tekst źródłowy | URL |
| DOI | 10.3390/ijms21072330 |
| Rok publikacji | 2020 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | International Journal of Molecular Sciences |
Abstract
In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering. PLA nonwovens modified with hydroxyapatite particles (HAp) were obtained using the electrospinning method. Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix. Hydrogels were cross-linked using a novel freezing-thawing-gelling method. A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.