Szczegóły publikacji
Opis bibliograficzny
Novel double hybrid-type bone cements based on calcium phosphates, chitosan and citrus pectin / Piotr PAŃTAK, Joanna P. CZECHOWSKA, Ewelina Cichoń, Aneta ZIMA // International Journal of Molecular Sciences [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1422-0067. — 2023 — vol. 24 iss. 17 art. no. 13455, s. 1–15. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 13–15, Abstr. — Publikacja dostępna online od: 2023-08-30
Autorzy (4)
- AGHPańtak Piotr
- AGHCzechowska Joanna
- Cichoń Ewelina
- AGHZima Aneta
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 148443 |
|---|---|
| Data dodania do BaDAP | 2023-09-13 |
| Tekst źródłowy | URL |
| DOI | 10.3390/ijms241713455 |
| Rok publikacji | 2023 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | International Journal of Molecular Sciences |
Abstract
In this work, the influence of the liquid phase composition on the physicochemical properties of double hybrid-type bone substitutes was investigated. The solid phase of obtained biomicroconcretes was composed of highly reactive α-tricalcium phosphate powder (α-TCP) and hybrid hydroxyapatite/chitosan granules (HA/CTS). Various combinations of disodium phosphate (Na2HPO4) solution and citrus pectin gel were used as liquid phases. The novelty of this study is the development of double-hybrid materials with a dual setting system. The double hybrid phenomenon is due to the interactions between polycationic polymer (chitosan in hybrid granules) and polyanionic polymer (citrus pectin). The chemical and phase composition (FTIR, XRD), setting times (Gillmore needles), injectability, mechanical strength, microstructure (SEM) and chemical stability in vitro were studied. The setting times of obtained materials ranged from 4.5 to 30.5 min for initial and from 7.5 to 55.5 min for final setting times. The compressive strength varied from 5.75 to 13.24 MPa. By incorporating citrus pectin into the liquid phase of the materials, not only did it enhance their physicochemical properties, but it also resulted in the development of fully injectable materials featuring a dual setting system. It has been shown that the properties of materials can be controlled by using the appropriate ratio of citrus pectin in the liquid phase.
