Szczegóły publikacji
Opis bibliograficzny
Sputum biomarkers during aspirin desensitization in nonsteroidal anti-inflammatory drugs exacerbated respiratory disease / Katarzyna Ewa Tyrak, [et al.], Adam ĆMIEL, [et al.] // Respiratory Medicine ; ISSN 0954-6111. — 2019 — vol. 152, s. 51–59. — Bibliogr. s. 58–59, Abstr. — Publikacja dostępna online od: 2019-04-30
Autorzy (13)
- Tyrak Katarzyna E.
- Kupryś-Lipińska Izabela
- Czarnobilska Ewa
- Jakieła Bogdan
- Pajdzik Kinga
- AGHĆmiel Adam
- Plutecka Hanna
- Koziej Mateusz
- Gawrońska Aleksandra
- Konduracka Ewa
- Kuna Piotr
- Sanak Marek
- Mastalerz Lucyna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 122011 |
|---|---|
| Data dodania do BaDAP | 2019-07-10 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.rmed.2019.04.021 |
| Rok publikacji | 2019 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Respiratory Medicine |
Abstract
Background: Aspirin desensitization (AD)is an effective and safe therapeutic option for patients with nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD). The mechanisms driving its beneficial effects remain poorly understood. Objective: To investigate the effect of long-term AD on clinical, biochemical and radiological changes in N-ERD patients. Methods: The study group consisted of twenty-three individuals with N-ERD who underwent AD, followed by ingestion of 325 mg aspirin twice daily. Twenty patients completed the 52 weeks of AD. The following evaluations were conducted at baseline and in the 52nd week of AD: (i)clinical: asthma exacerbations, Asthma Control Test (ACT), Visual Analogue Scale (VAS)for the assessment of nasal symptoms; (ii)blood and induced sputum supernatant (ISS)periostin, (iii)phenotypes based on induced sputum (IS)cells, (iiii)ISS and nasal lavage (NL)concentration of prostaglandin D 2 (PGD 2 ), prostaglandin E 2 (PGE 2 ), tetranor-PGD-M, tetranor-PGE-M, 8-iso-PGE 2 , leukotriene B 4 (LTB 4 ), LTC 4 , LTD 4 and LTE 4 , and urine LTE 4 . Results: A significant improvement was observed in ACT (P = 0.02)and VAS score (P = 0.008)in the 52nd week of AD. ISS periostin and IS eosinophil count decreased significantly in the 52nd week of AD (P = 0.04 and P = 0.01, respectively). ISS and NL eicosanoid concentrations did not change following long-term AD. Conclusion: and Clinical Relevance: AD is associated with a decrease in sputum periostin biosynthesis, which may prevent the recruitment of eosinophils into respiratory tissue and be one of explanation of the clinical benefits of AD. Long-term aspirin administration does not lead to an imbalance between pro- and anti-inflammatory ISS eicosanoids. © 2019 Elsevier Ltd
