Szczegóły publikacji
Opis bibliograficzny
Prostaglandin $E_{2}$ decrease in induced sputum of hypersensitive asthmatics during oral challenge with aspirin / Lucyna Mastalerz, Katarzyna E. Tyrak, Maria Ignacak, Ewa Konduracka, Filip Mejza, Adam ĆMIEL, Michał Buczek, Adrianna Kot, Krzysztof Oleś, Marek Sanak // Allergy ; ISSN 0105-4538. — 2019 — vol. 74 no. 5, s. 922–932. — Bibliogr. s. 931–932, Abstr. — Publikacja dostępna online od: 2018-11-17
Autorzy (10)
- Mastalerz Lucyna
- Tyrak Katarzyna E.
- Ignacak-Popiel Maria
- Konduracka Ewa
- Mejza Filip
- AGHĆmiel Adam
- Buczek Michał
- Kot Adrianna
- Oleś Krzysztof
- Sanak Marek
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 121912 |
|---|---|
| Data dodania do BaDAP | 2019-06-17 |
| Tekst źródłowy | URL |
| DOI | 10.1111/all.13671 |
| Rok publikacji | 2019 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Allergy |
Abstract
Background: A special regulatory role for prostaglandin E 2 (PGE 2 ) has been postulated in nonsteroidal anti-inflammatory drug (NSAID)–exacerbated respiratory disease (NERD). Objective: To investigate the effect of systemic aspirin (acetylsalicylic acid) administration on airway PGE 2 biosynthesis in induced sputum supernatant (ISS) among subjects with NERD or aspirin-tolerant asthma with chronic rhinosinusitis with nasal polyposis (ATA-CRSwNP), as well as healthy controls (HC). Methods: Induced sputum (IS) was collected from patients with NERD (n = 26), ATA-CRSwNP (n = 17), and HC (n = 21) at baseline and after aspirin challenge. Sputum differential cell count and IS supernatant (ISS) levels of prostanoids, PGE 2 , 8-iso-PGE 2 , tetranor-PGE-M, 8-iso-PGF 2 α, and leukotriene C 4 , D 4 , and E 4 , were determined using mass spectrometry. Urinary excretion of LTE 4 was measured by ELISA. Results: NERD subjects had elevated sputum eosinophilic count as compared to ATA-CRSwNP and HC (median NERD 9.1%, ATA-CRSwNP 2.1%, and HC 0.4%; P < 0.01). Baseline ISS levels of PGE 2 were higher in asthmatics as compared to HC at baseline (NERD vs HC P = 0.04, ATA-CRSwNP vs HC P < 0.05). Post-challenge ISS levels of PGE 2 compared to baseline significantly decreased in NERD and HC (P < 0.01 and P = 0.01), but not in ATA-CRSwNP. In NERD, a similar decrease in PGE 2 as in HC resulted from 2.8 times lower dose of aspirin. Conclusion: Aspirin-precipitated bronchoconstriction is associated with a decrease in airway PGE 2 biosynthesis. These results support the mechanism of PGE 2 biosynthesis inhibition as a trigger for bronchoconstriction in NERD.
