Szczegóły publikacji
Opis bibliograficzny
Diagnosis of ovarian tumour tissues by SR-FTIR spectroscopy: a pilot study / M. M. GRZELAK, P. M. WRÓBEL, M. LANKOSZ, Z. STĘGOWSKI, Ł. Chmura, D. Adamek, B. Hesse, H. Castillo-Michel // Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy ; ISSN 1386-1425. — 2018 — vol. 203, s. 48–55. — Bibliogr. s. 54–55, Abstr. — Publikacja dostępna online od: 2018-05-21
Autorzy (8)
- AGHGrzelak Maria
- AGHWróbel Paweł
- AGHLankosz Marek
- AGHStęgowski Zdzisław
- Chmura Łukasz
- Adamek Dariusz
- Hesse B.
- Castillo-Michel H.
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 117024 |
|---|---|
| Data dodania do BaDAP | 2018-10-11 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.saa.2018.05.070 |
| Rok publikacji | 2018 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Spectrochimica Acta, Part A, Molecular and Biomolecular Spectroscopy |
Abstract
Ovarian cancer is the seventh most common cancer among women across the world with very high mortality rates. Histology is considered the gold standard for tumour diagnosis. FTIR spectroscopy is relies on registering biochemical differences in the samples analysed, including biological specimens. Therefore, the Synchrotron radiation based-Fourier transform infrared spectroscopy (SR-FTIR) was used for the preliminary investigation of the molecular composition of the human, non-fixed ovarian neoplastic tissues with different type of biological potential. The study that was carried out on thin tissue sections, placed on barium fluoride infrared windows, was focused on investigating spatial distribution of the biochemical markers in various ovarian tumours. Since the structural constituents of tissues accumulate different molecules which may correspond to the specific type of ovarian tumours, the main goal of this study was to check if the mean intensities of the spectral lines of some bio-molecules can be treated as ovarian cancer bio-indicators. Moreover, an attempt to identify and understand the underlying biochemical changes associated with the disease was carried out. The major spectral differences in the frequency and intensities were identified as bonds of lipids, protein massif and nucleic acids. The results obtained suggest that Fourier transform infrared spectroscopy can be used as a supporting tool in the analysis of neoplastic ovarian tissue.
