Szczegóły publikacji
Opis bibliograficzny
Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration: physiochemical and microcomputer tomographical characterization / Timothy E. L. Douglas, [et al.], Aneta ZIMA, [et al.], Anna ŚLÓSARCZYK, [et al.] // Journal of Biomedical Materials Research. Part A ; ISSN 1549-3296. — 2018 — vol. 106 iss. 3, s. 822–828. — Bibliogr. s. 827–828, Abstr. — Publikacja dostępna online od: 2017-11-29
Autorzy (19)
- Douglas Timothy E. L.
- Schietse Josefien
- AGHZima Aneta
- Gorodzha Svetlana
- Parakhonskiy Bogdan V.
- Khalenkow Dmitry
- Shkarin Roman
- Ivanova Anna
- Baumbach Tilo
- Weinhardt Venera
- Stevens Christian V.
- Vanhoorne Valérie
- Vervaet Chris
- Balcaen Lieve
- Vanhaecke Frank
- AGHŚlósarczyk Anna
- Surmeneva Maria A.
- Surmenev Roman A.
- Skirtach Andre G.
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 111980 |
|---|---|
| Data dodania do BaDAP | 2018-02-10 |
| DOI | 10.1002/jbm.a.36277 |
| Rok publikacji | 2018 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Biomedical Materials Research, Part A |
Abstract
Mineralized hydrogels are increasingly gaining attention as biomaterials for bone regeneration. The most common mineralization strategy has been addition of preformed inorganic particles during hydrogel formation. This maintains injectability. One common form of bone cement is formed by mixing particles of the highly reactive calcium phosphate alpha-tricalcium phosphate (α-TCP) with water to form hydroxyapatite (HA). The calcium ions released during this reaction can be exploited to crosslink anionic, calcium-binding polymers such as the polysaccharide gellan gum (GG) to induce hydrogel formation. In this study, three different amounts of α-TCP particles were added to GG polymer solution to generate novel, injectable hydrogel-inorganic composites. Distribution of the inorganic phase in the hydrogel was studied by high resolution microcomputer tomography (µCT). Gelation occurred within 30 min. α-TCP converted to HA. µCT revealed inhomogeneous distribution of the inorganic phase in the composites. These results demonstrate the potential of the composites as alternatives to traditional α-TCP bone cement and pave the way for incorporation of biologically active substances and in vitro and in vivo testing.
