Szczegóły publikacji
Opis bibliograficzny
Ca:Mg:Zn:$CO_{3}$ and Ca:Mg:Zn:$CO_{3}$-tri- and bi-elemental carbonate microparticles for novel injectable self-gelling hydrogel-microparticle composites for tissue regeneration / Timothy E. L. Douglas, Katarzyna Sobczyk, Agata Łapa, [et al.], Katarzyna RECZYŃSKA, Krzysztof PIETRYGA, [et al.], Elżbieta PAMUŁA, [et al.] // Biomedical Materials ; ISSN 1748-6041. — 2017 — vol. 12 no. 2 art. no. 025015, s. 1–12. — Bibliogr. s. 12, Abstr. — Publikacja dostępna online od: 2017-03-24
Autorzy (21)
- Douglas Timothy E. L.
- AGHSobczyk Katarzyna
- AGHŁapa Agata
- Włodarczyk Katarzyna
- Brackman Gilles
- Vidiasheva Irina
- AGHReczyńska-Kolman Katarzyna
- AGHPietryga Krzysztof
- Schaubroeck David
- Bliznuk Vitaliy
- Voort Pascal van der
- Declercq Heidi A.
- Bulcke Jan Van den
- Samal Sangram K.
- Khalenkow Dmitry
- Parakhonskiy Bogdan V.
- Acker Joris Van
- Coenye Tom
- Lewandowska-Szumieł Małgorzata
- AGHPamuła Elżbieta
- Skirtach Andre G.
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 105841 |
|---|---|
| Data dodania do BaDAP | 2017-06-19 |
| Tekst źródłowy | URL |
| DOI | 10.1088/1748-605X/aa6200 |
| Rok publikacji | 2017 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Biomedical Materials |
Abstract
Injectable composites for tissue regeneration can be developed by dispersion of inorganic microparticles and cells in a hydrogel phase. In this study, multifunctional carbonate microparticles containing different amounts of calcium, magnesium and zinc were mixed with solutions of gellan gum (GG), an anionic polysaccharide, to form injectable hydrogel-microparticle composites, containing Zn, Ca and Mg. Zn and Ca were incorporated into microparticle preparations to a greater extent than Mg. Microparticle groups were heterogeneous and contained microparticles of differing shape and elemental composition. Zn-rich microparticles were 'star shaped' and appeared to consist of small crystallites, while Zn-poor, Ca-and Mg-rich microparticles were irregular in shape and appeared to contain lager crystallites. Zn-free microparticle groups exhibited the best cytocompatibility and, unexpectedly, Zn-free composites showed the highest antibacterial activity towards methicilin-resistant Staphylococcus aureus. Composites containing Zn-free microparticles were cytocompatible and therefore appear most suitable for applications as an injectable biomaterial. This study proves the principle of creating bi-and tri-elemental microparticles to induce the gelation of GG to create injectable hydrogel-microparticle composites.
