Szczegóły publikacji
Opis bibliograficzny
ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties / Kai Zheng, Miao Lu, Bogdan RUTKOWSKI, Xinyi Dai, Yuyun Yang, Nicola Taccardi, Urszula STACHEWICZ, Aleksandra CZYRSKA-FILEMONOWICZ, Norbert Hüser, Aldo R. Boccaccini // Journal of Materials Chemistry. B ; ISSN 2050-750X. — 2016 — vol. 4 iss. 48, s. 7936–7949. — Bibliogr. s. 7948–7949. — Publikacja dostępna online od: 2016-11-08
Autorzy (10)
- Zheng Kai
- Lu Miao
- AGHRutkowski Bogdan
- Dai Xinyi
- Yang Yuyun
- Taccardi Nicola
- AGHStachewicz Urszula
- AGHCzyrska-Filemonowicz Aleksandra
- Hüser Norbert
- Boccaccini Aldo Roberto
Dane bibliometryczne
| ID BaDAP | 103447 |
|---|---|
| Data dodania do BaDAP | 2017-01-23 |
| Tekst źródłowy | URL |
| DOI | 10.1039/c6tb02053d |
| Rok publikacji | 2016 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Materials Chemistry, B |
Abstract
Zinc (Zn)-containing materials have osteogenic and antibacterial activities while bioactive glass nanoparticles (BGN) show bone-bonding ability, as well as osteoconductive and osteoinductive properties. Zn-containing BGN are therefore considered to be promising materials for various biomedical applications, particularly in bone regeneration. In this study, we report a convenient method to prepare Zn-containing BGN by coating ZnO quantum dots (QDs) on BGN via electrostatic interactions. The synthesized ZnO-BGN nanocomposite particles are spherical and highly dispersed, and exhibit a unique fluorescence behavior under UV excitation, emitting three wavelengths in the violet, blue and green range. ZnO-BGN showed apatite-forming ability upon immersion in simulated body fluid, but their apatite formation was delayed compared to BGN. Interestingly, ZnO-BGN showed a rapid release of Zn ions at pH 4 but a far slower release at pH 7.4. ZnO-BGN also exhibited antibacterial effects on both Gram-positive and Gram-negative bacteria at the concentrations of 1, 0.1, and 0.01 mg mL-1. Higher concentrations could lead to stronger antibacterial effects. The LDH and live/dead assays indicated that ZnO-BGN had no significant cytotoxicity towards human mesenchymal stem cells (hMSC) at concentration of 0.1 and 0.01 mg mL-1, but ZnO-BGN inhibited the relative proliferation of hMSC compared to BGN and the control according to the MTT assay. Notably ZnO-BGN improved the osteogenic differentiation of hMSC as indicated by the determination of the alkaline phosphatase activity. In conclusion, coating quantum dots on BGN is a promising strategy to produce Zn-containing BGN. The synthesized ZnO-BGN are potential materials for bone regeneration, considering their apatite-forming ability, unique ion-release behavior, effective antibacterial activity, non-cytotoxicity, and osteogenic potential. © The Royal Society of Chemistry.
