Szczegóły publikacji
Opis bibliograficzny
Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate / Urszula POSADOWSKA, Martin Parizek, Elena Filova, Małgorzata Włodarczyk-Biegun, Marleen Kamperman, Lucie Bacakova, Elżbieta PAMUŁA // International Journal of Pharmaceutics ; ISSN 0378-5173. — 2015 — vol. 485 iss. 1–2, s. 31–40. — Bibliogr. s. 39–40, Abstr.
Autorzy (7)
- AGHCibor Urszula
- Parizek Martin
- Filova Elena
- Włodarczyk-Biegun Małgorzata
- Kamperman Marleen
- Bacakova Lucie
- AGHPamuła Elżbieta
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 88657 |
|---|---|
| Data dodania do BaDAP | 2015-04-14 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.ijpharm.2015.03.003 |
| Rok publikacji | 2015 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | International Journal of Pharmaceutics |
Abstract
Systemic administration of bisphosphonates, e.g. sodium alendronate (Aln) is characterized by extremely low bioavailability and high toxicity. To omit aforementioned drawbacks an injectable system for the intra-bone delivery of Aln based on Aln-loaded nanoparticles (NPs-Aln) suspended in a hydrogel matrix (gellan gum, GG) was developed. Aln was encapsulated in poly(lactide-co-glycolide) (PLGA 85:15) by solid-oil-water emulsification. Drug release tests showed that within 25 days all the encapsulated drug was released from NPs-Aln and the release rate was highest at the beginning and decreased with time. In contrast, by suspending NPs-Aln in a GG matrix, the release rate was significantly lower and more constant in time. The GG-NPs-Aln system was engineered to be easily injectable and was able to reassemble its structure after extrusion as shown by rheological measurements. In vitro studies showed that the GG-NPs-Aln was cytocompatible with MG-63 osteoblast-like cells and it inhibited RANKL-mediated osteoclastic differentiation of RAW 264.7 cells. The injectability, the sustained local delivery of small doses of Aln and the biological activity render the GG-NPs-Aln system promising for the local treatment of osteoporosis and other bone tissue disorders. © 2015 Published by Elsevier B.V.
