Szczegóły publikacji
Opis bibliograficzny
Chemically bonded, calcium phosphate based bioceramics with addition of calcium sulphate / J. CZECHOWSKA, D. SIEK, A. ZIMA, A. ŚLÓSARCZYK // Archives of Materials Science and Engineering ; ISSN 1897-2764. — Tytuł poprz.: Archives of Materials Science. — 2014 — vol. 66 iss. 1, s. 5–12. — Bibliogr. s. 11–12, Abstr.
Autorzy (4)
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 88124 |
|---|---|
| Data dodania do BaDAP | 2015-03-06 |
| Rok publikacji | 2014 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Archives of Materials Science and Engineering |
Abstract
Purpose: Calcium phosphate cements (CPCs) are extensively used as synthetic bone grafts due to their excellent bioactivity, moldability and ability to set in vivo. Although there are some commercial CPCs in the market, there are many ongoing research directed mainly to improve some of their properties, such as mechanical strength, cohesion or resorbability. The purpose of the study was to develop a more systematic approach for the formulations of CPCs and to obtain complex composite that will be gradually resorbed in vivo. Design/methodology/approach: In the present studies cements composed of different ratios of α-TCP, Mg<sup>2+</sup>/CO<sub>3<sub><sup>2-</sup> co-substituted hydroxyapatite (MgCHA) and calcium sulphate were developed. The obtained materials were characterized in terms of setting time, compressive strength and open porosity. XRD technique was employed to determine the phase composition of the initial powders and the final materials. Chemical stability of the studied materials was checked. Bioactive potential of the bone cements was evaluated in accordance to Kokubo’s protocol. Findings: The investigated materials possess excellent handling properties, appropriate setting times (initial: 6-8 min, final-17-21 min) and compressive strength comparable to cancellous bone (6-12 MPa). The expected gradual resorption of composites (resorbability: CSD » α-TCP > MgCHA) is believed to facilitate a healing process and stimulate bone regeneration. Research limitations/implications: Further in vitro and in vivo experiments need to be done to confirm cytocompatibility of these biomaterials. Originality/value: The new chemically bonded bioceramics with addition of calcium sulphate was developed. A systematic approach for the formulations of CPCs on the basis of α-TCP, MgCHA and calcium sulphate was performed. The obtained chemically bonded bioceramics may have a chance to be apply as bone substitutes in low load bearing places.
