Szczegóły publikacji
Opis bibliograficzny
Zinc deficiency in rats in associated with up-regulation of hippocampal NMDA receptor / Urszula Doboszewska, Magdalena Sowa-Kućma, Katarzyna Młyniec, Bartłomiej Pochwat, Malgorzata Hołuj, Beata OSTACHOWICZ, Andrzej Pilc, Gabriel Nowak, Bernadeta Szewczyk // Progress in Neuro-Psychopharmacology & Biological Psychiatry ; ISSN 0278-5846. — 2015 — vol. 56, s. 254–263. — Bibliogr. s. 261–263, Abstr. — K. Młyniec - afiliacja: Jagiellonian University Medical College
Autorzy (9)
- Doboszewska Urszula
- Sowa-Kućma Magdalena
- Młyniec Katarzyna
- Pochwat Bartłomiej
- Hołuj Małgorzata
- AGHOstachowicz Beata
- Pilc Andrzej
- Nowak Gabriel
- Szewczyk Bernadeta
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 88029 |
|---|---|
| Data dodania do BaDAP | 2015-03-02 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.pnpbp.2014.09.013 |
| Rok publikacji | 2015 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Progress in Neuro-Psychopharmacology & Biological Psychiatry |
Abstract
Rationale: Data indicated that zinc deficiency may contribute to the development of depression; however changes induced by zinc deficiency are not fully described. Objectives: In the present paper we tested whether the dietary zinc restriction in rats causes alterations in N-methyl-D-aspartate receptor (NMDAR) subunits in brain regions that are relevant to depression. Methods: Male Sprague Dawley rats were fed a zinc adequate diet (ZnA, 50 mg Zn/kg) or a zinc deficient diet (ZnD, 3 mg Zn/kg) for 4 or 6 weeks. Then, the behavior of the rats was examined in the forced swim test, sucrose intake test and social interaction test. Western blot assays were used to study the alterations in NMDAR subunits GluN2A and GluN2B and proteins associated with NMDAR signaling in the hippocampus (Hp) and prefrontal cortex (PFC). Results: Following 4 or 6 weeks of zinc restriction, behavioral despair, anhedonia and a reduction of social behavior occurred in rats with concomitant increased expression of GluN2A and GluN2B and decreased expression of the PSD-95, p-CREB and BDNF protein levels in the Hp. The up-regulation of GluN2A protein was also found in the PFC, but only after prolonged (6 weeks) zinc deprivation. Conclusions: The procedure of zinc restriction in rats causes behavioral changes that share some similarities to the pathophysiology of depression. Obtained data indicated that depressive-like behavior induced by zinc deficiency is associated with the changes in NMDAR signaling pathway. (C) 2014 Elsevier Inc. All rights reserved.
