Szczegóły publikacji
Opis bibliograficzny
$T_{1}–T_{2}$ Dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes / Agnieszka Szpak, Sylwia Fiejdasz, Witold PRENDOTA, Tomasz STRĄCZEK, Czesław KAPUSTA, Janusz SZMYD, Maria Nowakowska, Szczepan Zapotoczny // Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology ; ISSN 1388-0764. — 2014 — vol. 16 iss. 11 art. no. 2678, s. 1–11. — Bibliogr. s. 11, Abstr.
Autorzy (8)
- Szpak Agnieszka
- Fiejdasz Sylwia
- AGHPrendota Witold
- AGHStrączek Tomasz
- AGHKapusta Czesław
- AGHSzmyd Janusz
- Nowakowska Maria
- Zapotoczny Szczepan
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 87724 |
|---|---|
| Data dodania do BaDAP | 2015-02-12 |
| Tekst źródłowy | URL |
| DOI | 10.1007/s11051-014-2678-6 |
| Rok publikacji | 2014 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Nanoparticle Research |
Abstract
Dual-mode MRI contrast agents consisting of superparamagnetic iron oxide nanoparticle (SPION) cores and gadolinium ions associated with the ionic chitosan protecting layer were synthesized and studied. Gadolinium ions were introduced into the coating layer via direct complex formation on the nanoparticles surface, covalent attachment or electrostatically driven deposition of the preformed Gd complex. The modified SPIONs having hydrodynamic diameters ca. 100 nm form stable, well-defined dispersions in water and have excellent magnetic properties. Physiochemical properties of those new materials were characterized using e.g., FTIR spectroscopy, dynamic light scattering, X-ray fluorescence, TEM, and vibrating sample magnetometry. They behave as superparamagnetics and shorten both T-1 and T-2 proton relaxation times, thus influencing both r(1) and r(2) relaxivity values that reach 53.7 and 375.5 mM(-1) s(-1), respectively, at 15 MHz. The obtained materials can be considered as highly effective contrast agents for low-field MRI, particularly useful at permanent magnet-based scanners.
