Szczegóły publikacji
Opis bibliograficzny
Metabolism of cryptic peptides derived from neuropeptide FF precursors: the involvement of insulin-degrading enzyme / Giuseppe Grasso, Przemysław MIELCZAREK, Magdalena NIEDZIÓŁKA, Jerzy SILBERRING // International Journal of Molecular Sciences [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1422-0067. — 2014 — vol. 15 iss. 9, s. 16787–16799. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 16797–16799, Abstr. — Publikacja dostępna online od: 2014-09-22. — J. Sillbering – dod. afiliacja: Centre for Polymer and Carbon Materials
Autorzy (4)
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 84683 |
|---|---|
| Data dodania do BaDAP | 2014-10-01 |
| Tekst źródłowy | URL |
| DOI | 10.3390/ijms150916787 |
| Rok publikacji | 2014 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | International Journal of Molecular Sciences |
Abstract
The term “cryptome” refers to the subset of cryptic peptides with bioactivities that are often unpredictable and very different from the parent protein. These cryptic peptides are generated by proteolytic cleavage of proteases, whose identification in vivo can be very challenging. In this work, we show that insulin-degrading enzyme (IDE) is able to degrade specific amino acid sequences present in the neuropeptide pro-NPFFA (NPFF precursor), generating some cryptic peptides that are also observed after incubation with rat brain cortex homogenate. The reported experimental findings support the increasingly accredited hypothesis, according to which, due to its wide substrate selectivity, IDE is involved in a wide variety of physiopathological processes. © 2014 by the authors; licensee MDPI, Basel, Switzerland.