Szczegóły publikacji
Opis bibliograficzny
Gentamicin release from biodegradable poly-L-lactide based composites for novel intramedullary nails / Anna MORAWSKA-CHOCHÓŁ, Patrycja DOMALIK-PYZIK, Jan CHŁOPEK, Barbara SZARANIEC, Jacek Sterna, Magdalena Rzewuska, Maciej Boguń, Rafael Kucharski, Przemysław MIELCZAREK // Materials Science and Engineering. C, Biomimetic Materials, Sensors and Systems ; ISSN 0928-4931. — 2014 — vol. 45, s. 15–20. — Bibliogr. s. 20, Abstr.
Autorzy (9)
- AGHMorawska-Chochół Anna
- AGHDomalik-Pyzik Patrycja
- AGHChłopek Jan
- AGHSzaraniec Barbara
- Sterna Jacek
- Rzewuska Magdalena
- Boguń Maciej
- Kucharski Rafael
- AGHMielczarek Przemysław
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 84581 |
|---|---|
| Data dodania do BaDAP | 2014-09-29 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.msec.2014.08.059 |
| Rok publikacji | 2014 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Materials Science and Engineering, C, Materials for Biological Applications |
Abstract
One of the major problems in orthopedic surgery is infection associated with implantation. The treatment is a very difficult and long-term process. A solution to this issue can be the use of implants which additionally constitute an antibiotic carrier preventing the development of an infection. Prototypes of biodegradable intramedullary nails made of three different composites with a poly(l-lactide) matrix were designed. The nails served as gentamicin sulfate (GS) carrier - an antibiotic commonly used in the treatment of osteomyelitis. The matrix was reinforced with carbon fibers (CF), alginate fibers (Alg) and magnesium alloy wires (Mg), as well as modified with bioactive particles of tricalcium phosphate (TCP) in various systems. In this way, novel, multi-phase and multifunctional degradable intramedullary nails were obtained. The tests demonstrated strong dependence between the type of the modifying phase introduced into the composite, and the rate of drug release. Introduction of gentamicin into the nail structure strengthened and prolonged antibacterial activity of the nails. © 2014 Elsevier B.V.
