Szczegóły publikacji
Opis bibliograficzny
Titanium coated with functionalized carbon nanotubes : a promising novel material for biomedical application as an implantable orthopaedic electronic device / Agata Przekora, Aleksandra BENKO, Marek NOCUŃ, Jan WYRWA, Marta BŁAŻEWICZ, Grażyna Ginalska // Materials Science and Engineering. C, Biomimetic Materials, Sensors and Systems ; ISSN 0928-4931. — 2014 — vol. 45, s. 287–296. — Bibliogr. s. 295, Abstr.
Autorzy (6)
- Przekora Agata
- AGHBenko Aleksandra
- AGHNocuń Marek
- AGHWyrwa Jan
- AGHBłażewicz Marta
- Ginalska Grażyna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 84120 |
|---|---|
| Data dodania do BaDAP | 2014-09-24 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.msec.2014.09.025 |
| Rok publikacji | 2014 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Materials Science and Engineering, C, Materials for Biological Applications |
Abstract
The aim of the study was to fabricate titanium (Ti) material coated with functionalized carbon nanotubes (f-CNTs) that would have potential medical application in orthopaedics as an implantable electronic device. The novel biomedical material (Ti-CNTs-H2O) would possess specific set of properties, such as: electrical conductivity, non-toxicity, and ability to inhibit connective tissue cell growth and proliferation protecting the Ti-CNTs-H2O surface against covering by cells. The novel material was obtained via an electrophoretic deposition of CNTs-H2O on the Ti surface. Then, physicochemical, electrical, and biological properties were evaluated. Electrical property evaluation revealed that a Ti-CNTs-H2O material is highly conductive and X-ray photoelectron spectroscopy analysis demonstrated that there are mainly COOH groups on the Ti-CNTs-H2O surface that are found to inhibit cell growth. Biological properties were assessed using normal human foetal osteoblast cell line (hFOB 1.19). Conducted cytotoxicity tests and live/dead fluorescent staining demonstrated that Ti-CNTs-H2O does not exert toxic effect on hFOB cells. Moreover, fluorescence laser scanning microscope observation demonstrated that Ti-CNTs-H2O surface retards to a great extent cell proliferation. The study resulted in successful fabrication of highly conductive, non-toxic Ti-CNTs-H2O material that possesses ability to inhibit osteoblast proliferation and thus has a great potential as an orthopaedic implantable electronic device. © 2014 Elsevier B.V.
