Szczegóły publikacji
Opis bibliograficzny
Synthesis of metabolites of paracetamol and cocaine via photooxidation on ${TiO_{2}}$ catalyzed by UV light / Hanna RAOOF, Przemysław MIELCZAREK, Katarzyna A. Michalow, Mieczysław RĘKAS, Jerzy SILBERRING // Journal of Photochemistry and Photobiology. B, Biology ; ISSN 1011-1344. — 2013 — vol. 118, s. 49–57. — Bibliogr. s. 56–57, Abstr. — Jerzy Silberring – dod. afiliacja: Laboratory of High Performance Ceramics, Empa Swiss Federal Laboratories for Materials Science & Technology
Autorzy (5)
- AGHRaoof Hana
- AGHMielczarek Przemysław
- Michalow Katarzyna A.
- AGHRękas Mieczysław
- AGHSilberring Jerzy
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 71014 |
|---|---|
| Data dodania do BaDAP | 2013-02-01 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.jphotobiol.2012.10.013 |
| Rok publikacji | 2013 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Photochemistry and Photobiology, B, Biology |
Abstract
Prediction and synthesis of drug metabolites generated by photodegradation using TiO2/UV system in aqueous solution was performed to monitor illicit drugs and to support legal actions against drug dealers. Metabolism of paracetamol and cocaine applied as exemplary compounds was monitored by liquid chromatography mass spectrometry (LC-MS/MS) and direct analysis by electrospray ionization mass spectrometry (ESI-MS/MS). The experiments proved that simulated metabolic pathways of the drug samples are efficient and lead to the formation of products that are observed using living organisms or hepatocyte microsomal preparations. Routinely, TiO2 nanopowders are used for complete degradation of unwanted waste to protect environment. We applied such system for prediction of potential metabolites of harmful substances, such as cocaine. The results demonstrate that TiO2/UV oxidative system can be an efficient, complementary method to the in vivo approaches to obtain important metabolites for further studies. Investigations using such methodology may be helpful for toxicologists providing a vital knowledge on metabolites derived from e.g. newly introduced cognitive enhancers (designer drugs), and home-made substances prepared from the over-the-counter tablets (legal highs).
