Szczegóły publikacji
Opis bibliograficzny
Time course of zinc deprivation-induced alterations of mice behavior in the forced swim test / Katarzyna Młyniec, Claire Linzi Davies, Bogusława Budziszewska, Włodzimierz Opoka, Witold RECZYŃSKI, Magdalena Sowa-Kućma, Urszula Doboszewska, Andrzej Pilc, Gabriel Nowak // Pharmacological Reports ; ISSN 1734-1140. — 2012 — vol. 64 no. 3, s. 567–575. — Bibliogr. s. 574–575, Abstr. — Publikacja dostępna online od: 2012-12-30. — K. Młyniec - afiliacja: Jagiellonian University Medical College
Autorzy (9)
- Młyniec Katarzyna
- Davies Claire Linzi
- Budziszewska Bogusława
- Opoka Włodzimierz
- AGHReczyński Witold
- Sowa-Kućma Magdalena
- Doboszewska Urszula
- Pilc Andrzej
- Nowak Gabriel
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 67243 |
|---|---|
| Data dodania do BaDAP | 2012-08-16 |
| Tekst źródłowy | URL |
| DOI | 10.1016/S1734-1140(12)70852-6 |
| Rok publikacji | 2012 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Pharmacological Reports |
Abstract
Background Zinc is an important trace element essential for numerous bodily functions. It is believed that a deficiency of zinc can lead to various conditions, including depression, on which this study is focused. It is still not known if hypozincemia leads to the development of depression or whether zinc deficiency is a result of depression. It is hypothesized that zinc may be a therapeutic agent or supplement that would help to reverse the symptoms of this disease. Methods In the present study, the behavior of mice was assessed 2,4, and 10 weeks following administration of a zinc deficient diet. To evaluate animal activity we used the forced swim test (FST). Results After 2-week zinc deprivation we demonstrated a significant reduction in the immobility time. However, after 4 and 10 weeks of zinc deprivation the mice exhibited an increased immobility time. There were no changes in locomotor activity at each time period. After 2-, 4- and 10-week zinc deprivation and the subsequent FST, serum zinc concentration was decreased and determined to be 59, 61 and 20%, respectively, compared with appropriate controls. The serum corticosterone concentration in mice after 2-, 4-and 10-week zinc deprivation and subjected to the FST was also assessed, whereby the differences between the control and experimental animals were demonstrated (increased by: 11, 97 and 225%, respectively). Conclusions The obtained results indicate that zinc deprivation induced “pro-depressive” behavior (after the initial period of “anti-depressive” behavior). This pro-depressive behavior correlates with enhanced serum corticosterone concentration.
