Szczegóły publikacji
Opis bibliograficzny
Fabrication and mechanical properties of PLA/HA composites: a study of in vitro degradation / J. Russias, E. Saiz, R. K. Nalla, K. Gryń, R. O. Ritchie, A. P. Tomsia // Materials Science and Engineering. C, Biomimetic Materials, Sensors and Systems ; ISSN 0928-4931. — 2006 — vol. 26 iss. 8, s. 1289–1295. — Bibliogr. s. 1295, Abstr. — Publikacja dostępna online od: 2005-10-06. — K. Gryń - afiliacja: Lawrence Berkeley National Laboratory, United States. — 1st Symposium on Biological materials science held at the 2005 TMA Annual Meeting : San Francisco, USA, February 13-17, 2005
Autorzy (6)
- Russias Julie
- Saiz Eduardo
- Nalla Ravi K.
- Gryń Karol
- Ritche Robert O.
- Tomsia Antoni P.
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 57764 |
|---|---|
| Data dodania do BaDAP | 2011-03-01 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.msec.2005.08.004 |
| Rok publikacji | 2006 |
| Typ publikacji | referat w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Materials Science and Engineering, C, Materials for Biological Applications |
Abstract
The adverse effects of stress shielding from the use of high-modulus metallic alloy bio-implant materials has led to increased research into developing polymer-ceramic composite materials that match the elastic modulus of human bone. Of particular interest are poly-L-lactic acid-hydroxyapatite (PLA/HA)-based composites which are fully resorbable in vivo. However, their bioresorbability has a deleterious effect on the mechanical properties of the implant. The purpose of this study is to investigate, from a micromechanistic perspective, the in vitro degradation behavior of such composites manufactured using a simple hot-pressing route for two different hydroxyapatite particles: a fine-grained (average particle size similar to 5 mu m) commercial powder or coarser whiskers (similar to 25-30 mu m long, similar to 5 mu m in diameter). We observed that composites with ceramic contents ranging between 70 and 85 wt.% have mechanical properties that match reasonably those of human cortical bone. However, the properties deteriorate with immersion in Hanks' Balanced Salt Solution due to the degradation of the polymer phase. The degradation is more pronounced in samples with larger ceramic content due to the dissolution of the smaller amount of polymer between the ceramic particles. (c) 2005 Elsevier B.V. All rights reserved.
