Szczegóły publikacji
Opis bibliograficzny
In vivo biocompatibility assessment of (PTFE-PVDF-PP) terpolymer-based membrane with potential application for glaucoma treatment / Rafał Leszczyński, Ewa STODOLAK, Jarosław Wieczorek, Jolanta Orłowska-Heitzman, Teresa GUMUŁA, Stanisław BŁAŻEWICZ // Journal of Materials Science: Materials in Medicine ; ISSN 0957-4530. — 2010 — vol. 21 iss. 10, s. 2843–2851. — Bibliogr. s. 2850–2851, Abstr.
Autorzy (6)
- Leszczyński Rafał
- AGHStodolak-Zych Ewa
- Wieczorek Jarosław
- Orłowska-Heitzman Jolanta
- AGHGumuła Teresa
- AGHBłażewicz Stanisław
Dane bibliometryczne
| ID BaDAP | 55802 |
|---|---|
| Data dodania do BaDAP | 2011-01-07 |
| Tekst źródłowy | URL |
| DOI | 10.1007/s10856-010-4132-3 |
| Rok publikacji | 2010 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Materials Science-Materials in Medicine |
Abstract
The aim of the work was to evaluate the in vivo biological behaviour of polymeric membrane materials for glaucoma implants. The base material was biostable synthetic terpolymer (PTFE–PVDF–PP) with proved biocompability (PN-EN ISO 10993). The samples manufactured in the form a membrane were subjected to chemical and physical treatment to create an open pore system within the polymer matrix. As a porogenic phase biodegradable natrium alginate in a fibrous form was employed. The non-perforating deep sclerectomy technique was performed in a rabbit model. The clinical observations were made after 14 and 30 days. During the study clinical symptoms of a moderate degree were observed, and histopathological changes were typical for foreign body implantation. At the end stage of the study no significant difference in histopathological assessment was found between control and experimental group. Similarities observed in both groups and relatively mild histopathological changes in the tissue surrounding the implant indicate that the observed symptoms come from a deep scleral trauma caused by surgery, and not by the presence of the implant itself.