Szczegóły publikacji
Opis bibliograficzny
A combined approach of endobronchial and endoscopic ultrasound-guided needle aspiration in the radiologically normal meiastinum in non-small-cell lung cancer staging – a prospective trial / Artur Szlubowski, Marcin Zieliński, Jerzy Soja, Jouke T. Annema, Witold Sośnicki, Magdalena Jakubiak, Juliusz Pankowski, Adam ĆMIEL // European Journal of Cardio-Thoracic Surgery ; ISSN 1010-7940 . — 2010 — vol. 37 iss. 5, s. 1175–1179. — Bibliogr. s. 1179, Abstr. — Publikacja dostępna online od: 2010-05-01
Autorzy (8)
- Szlubowski Artur
- Zieliński Marcin
- Soja Jerzy
- Annema Jouke T.
- Sośnicki Witold
- Jakubiak Magdalena
- Pankowski Juliusz
- AGHĆmiel Adam
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 52872 |
|---|---|
| Data dodania do BaDAP | 2010-08-23 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.ejcts.2009.11.015 |
| Rok publikacji | 2010 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | European Journal of Cardio-Thoracic Surgery |
Abstract
Objectives: This prospective study aimed to assess the diagnostic yield of the combined approach – endobronchial (EBUS) and endoscopic (EUS) ultrasound-guided needle aspiration (combined ultrasound-needle aspiration (CUS-NA)) in the radiologically normal mediastinum in non-small-cell lung cancer (NSCLC) staging. Methods: CUS-NA was performed simultaneously under local anaesthesia and sedation in consecutive NSCLC patients with mediastinal nodes that were not enlarged on CT (stage IA–IIB). All patients with negative CUS-NA subsequently underwent the transcervical extended bilateral mediastinal lymphadenectomy (TEMLA) as a confirmatory test. Results: A total of 120 NSCLC patients underwent CUS-NA between 1 January 2008 and 31 December 2008. There were 318 mediastinal nodes biopsied (158 EBUS-NA – stations: 2R – 2, 2L – 1, 4R – 34, 4L – 33 and 7 – 88 and 160 EUS-NA – stations: 4L – 57, 7 – 101 and 9 – 2). CUS-NA revealed metastatic lymph node involvement in 19 of 120 patients (16%) and in 31 of 318 biopsies (10%). The prevalence was 22%. In 99 patients with negative CUS-NA, who underwent subsequent TEMLA, metastatic nodes were diagnosed in nine patients (8%) in 11 stations: 2R – 2, 4R – 4, 4L – 1, 5 – 3 and 7 – 1. In all but one patient there were ‘minimal N2’ only. Diagnostic sensitivity, specificity, total accuracy, positive predictive value (PPV) and negative predictive value (NPV) of CUS-NA for normal mediastinum was 68% (95% confidence interval (CI): 48–84), 98% (95% CI: 92–100), 91% (95% CI: 86–96), 91% (95% CI: 70–99) and 91% (95% CI: 83–96), respectively. The sensitivity of CUS-NA was significantly higher than with EBUS-NA alone (p = 0.04) and higher, close to the level of significance than with EUS-NA alone (p = 0.07). The NPV of all techniques was high and that of CUS-NA was significantly higher than EBUS-NA alone and EUS-NA alone (p = 0.01, p = 0.03). No complications of CUS-NA were observed. Conclusions: In the radiologically normal mediastinum, CUS-NA is a highly effective and safe technique in NSCLC staging and, if negative, a surgical diagnostic exploration of the mediastinum may be omitted.
