Szczegóły publikacji
Opis bibliograficzny
Drug delivery system of curcumin to the lungs based on poly(3-alloxyloxy-1,2-propylene succinate)-sebacic acid copolymers / Karolina KNAP, Konrad KWIECIEŃ, Jonasz CZAJKOWSKI, Rafał Szostecki, Daria Niewolik, Katarzyna Jaszcz, Peter Olinga, Katarzyna RECZYŃSKA-KOLMAN, Elżbieta PAMUŁA // Journal of Pharmaceutical Analysis ; ISSN 2095-1779 . — 2026 — vol. 16 iss. 7 art. no. 101434, s. 1-16. — Bibliogr. s. 15-16, Abstr. — Publikacja dostępna online od: 2025-08-14
Autorzy (9)
- AGHKnap-Matlęga Karolina
- AGHKwiecień Konrad
- AGHCzajkowski Jonasz
- AGHSzostecki Rafał
- Niewolik Daria
- Jaszcz Katarzyna
- Olinga Peter
- AGHReczyńska-Kolman Katarzyna
- AGHPamuła Elżbieta
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 169330 |
|---|---|
| Data dodania do BaDAP | 2026-09-14 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.jpha.2025.101434 |
| Rok publikacji | 2026 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Journal of Pharmaceutical Analysis |
Abstract
Polyanhydrides are attractive materials for drug delivery matrices as a result of their cytocompatibility and fast degradation rate. Here, we synthesized and characterized copolymers of poly(3-allyloxy-1,2-propylene succinate) (PSAGE) and sebacic acid (SBA). The successful polymerization was confirmed by proton nuclear magnetic resonance (H-1 NMR) and Fourier transform infrared (FTIR) spectroscopy analyses. The material with PSAGE and 60% of SBA copolymer (PSAGE-SBA60) was more hydrophilic than the PSAGE and 80% of SBA copolymer (PSAGE-SBA80) (water contact angle 82.2 degrees +/- 11.6 degrees vs. 98.6 degrees +/- 8.9 degrees, respectively). PSAGE-SBA60 also had a lower molecular weight than PSAGE-SBA80 (M-n = 6400 Da vs. 9800 Da). Both polyanhydrides were used to encapsulate curcumin (CUR) as a potential anti-inflammatory, antimicrobial and anticancer agent. The unloaded microparticles (MPs) and CUR-loaded MPs were produced using the emulsification/solvent evaporation method. The CUR was uniformly distributed within the MPs, as confirmed by fluorescence microscopy. All MPs had a geometric diameter < 5 mu m and their surface charge was negative. MPs_PSAGE-SBA80 + CUR had the best aerodynamic properties, as shown by laser diffraction measurements and flowability parameters, i.e., Carr index and Hausner ratio. The MPs obtained from PSAGE-SBA60 degraded faster than those of PSAGE-SBA80. All MPs were noncytotoxic at a concentration of up to 100 mu g/mL in the in vitro model (BEAS-2B lung epithelial cells) and ex vivo precision-cut tissue slices (PCTSs) rat model. The developed MPs are promising CUR carriers for pulmonary delivery in a dry powder formulation.
